| Online-Ressource |
Verfasst von: | Gümüs, Katja S. [VerfasserIn]  |
| Keese, Michael [VerfasserIn]  |
| Weber, Christian Friedrich [VerfasserIn]  |
| Geisen, Christof [VerfasserIn]  |
| Miesbach, Wolfgang [VerfasserIn]  |
Titel: | Prospective evaluation of the pre-, intra-, and postoperative kinetics of ADAMTS-13, von Willebrand Factor, and Interleukin-6 in vascular surgery |
Verf.angabe: | Katja Susanne Häußler, Michael Keese, Christian Friedrich Weber, Christof Geisen, and Wolfgang Miesbach |
E-Jahr: | 2020 |
Jahr: | October 6, 2020 |
Umfang: | 9 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Gesehen am 04.03.2025 |
Titel Quelle: | Enthalten in: Clinical and applied thrombosis, hemostasis |
Ort Quelle: | Thousand Oaks, Calif. : Sage, 1995 |
Jahr Quelle: | 2020 |
Band/Heft Quelle: | 26(2020), Seite 1-9 |
ISSN Quelle: | 1938-2723 |
Abstract: | Postoperative thrombotic thrombocytopenic purpura (TTP) shows clinical presentation similar to classical TTP, whereas exact pathophysiological contexts remain unexplained. In this study, we investigated intraoperative and postoperative changes in ADAMTS-13 (a disintegrin and metalloprotease with thrombospondin type 1 motifs, member 13), von Willebrand factor (VWF), large VWF multimers, and interleukin-6 (IL-6) in vascular surgery patients. The objective was to compare the impact of endovascular, peripheral, and aortic surgery on target parameters which are supposed to play a role in surgery-associated TTP. A total of 93 vascular surgery patients were included and divided into 4 groups according to the specific type of intervention they underwent. Blood samples were taken preoperatively, intraoperatively, and postoperatively on days 2 and 4. The ADAMTS-13 activity decreased significantly in 3 of the 4 groups during surgery (from median 81% to 49%, P < .001, in the group undergoing aortoiliacal interventions), whereas the percentage of large VWF multimers increased in all groups of patients. von Willebrand factor antigen increased significantly in all groups on postoperative day 2 and IL-6 increased significantly in the intraoperative and early postoperative period. There was no significant correlation between the intraoperative decrease in ADAMTS-13 and the increase in VWF or IL-6. No patient in this study showed clinical picture of TTP; the precise cause and clinical significance of moderately reduced ADAMTS-13 activity in the perioperative setting have not yet been definitely determined. |
DOI: | doi:10.1177/1076029620930273 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1177/1076029620930273 |
| kostenfrei: Volltext: https://journals.sagepub.com/doi/10.1177/1076029620930273 |
| DOI: https://doi.org/10.1177/1076029620930273 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1919058974 |
Verknüpfungen: | → Zeitschrift |
Prospective evaluation of the pre-, intra-, and postoperative kinetics of ADAMTS-13, von Willebrand Factor, and Interleukin-6 in vascular surgery / Gümüs, Katja S. [VerfasserIn]; October 6, 2020 (Online-Ressource)