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| Verfasst von: | Li, Zhe [VerfasserIn]  |
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| | Obraztsova, Anna S. [VerfasserIn] |
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| | Shang, Fuwei [VerfasserIn] |
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| | Oludada, Opeyemi Ernest [VerfasserIn] |
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| | Malapit, Joshua Reginald [VerfasserIn] |
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| | Busch, Katrin [VerfasserIn] |
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| | Straaten, Monique van [VerfasserIn] |
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| | Stebbins, Erec [VerfasserIn] |
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| | Murugan, Rajagopal [VerfasserIn] |
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| | Wardemann, Hedda [VerfasserIn] |
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| Titel: | Affinity-independent memory B cell origin of the early antibody-secreting cell response in naive individuals upon SARS-CoV-2 vaccination |
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| Verf.angabe: | Zhe Li, Anna Obraztsova, Fuwei Shang, Opeyemi Ernest Oludada, Joshua Malapit, Katrin Busch, Monique van Straaten, Erec Stebbins, Rajagopal Murugan, and Hedda Wardemann |
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| E-Jahr: | 2024 |
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| Jahr: | 10 September 2024 |
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| Umfang: | 16 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 20. August 2024, Artikelversion: 10. September 2024 ; Gesehen am 05.03.2025 |
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| Titel Quelle: | Enthalten in: Immunity |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1994 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 57(2024), 9, Seite 2191-2201.e1-e5 |
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| ISSN Quelle: | 1097-4180 |
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| Abstract: | Memory B cells (MBCs) formed over the individual’s lifetime constitute nearly half of the circulating B cell repertoire in humans. These pre-existing MBCs dominate recall responses to their cognate antigens, but how they respond to recognition of novel antigens is not well understood. Here, we tracked the origin and followed the differentiation paths of MBCs in the early anti-spike (S) response to mRNA vaccination in SARS-CoV-2-naive individuals on single-cell and monoclonal antibody levels. Pre-existing, highly mutated MBCs showed no signs of germinal center re-entry and rapidly developed into mature antibody-secreting cells (ASCs). By contrast, and despite similar levels of S reactivity, naive B cells showed strong signs of antibody affinity maturation before differentiating into MBCs and ASCs. Thus, pre-existing human MBCs differentiate into ASCs in response to novel antigens, but the quality of the humoral and cellular anti-S response improved through the clonal selection and affinity maturation of naive precursors. |
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| DOI: | doi:10.1016/j.immuni.2024.07.023 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.immuni.2024.07.023 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S1074761324003728 |
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| | DOI: https://doi.org/10.1016/j.immuni.2024.07.023 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | affinity maturation |
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| | germinal center |
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| | humoral immunity |
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| | mRNA vaccination |
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| | pre-existing memory B cells |
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| | SARS-CoV-2 |
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| | somatic hypermutation |
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| K10plus-PPN: | 1919132066 |
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| Verknüpfungen: | → Zeitschrift |
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Affinity-independent memory B cell origin of the early antibody-secreting cell response in naive individuals upon SARS-CoV-2 vaccination / Li, Zhe [VerfasserIn]; 10 September 2024 (Online-Ressource)
