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Status: Bibliographieeintrag

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Verfasst von:Weishorn, Johannes [VerfasserIn]   i
 Niemeyer, Philipp [VerfasserIn]   i
 Angele, Peter [VerfasserIn]   i
 Spahn, Gunter [VerfasserIn]   i
 Tischer, Thomas [VerfasserIn]   i
 Renkawitz, Tobias [VerfasserIn]   i
 Bangert, Yannic [VerfasserIn]   i
Titel:Secondary matrix-associated autologous chondrocyte implantation after failed cartilage repair shows superior results when combined with autologous bone grafting
Titelzusatz:findings from the German Cartilage Registry (KnorpelRegister DGOU)
Verf.angabe:Johannes Weishorn, Philipp Niemeyer, Peter Angele, Gunther Spahn, Thomas Tischer, Tobias Renkawitz, Yannic Bangert
Ausgabe:Online version of record before inclusion in an issue
E-Jahr:2024
Jahr:15 September 2024
Umfang:10 S.
Fussnoten:Gesehen am 05.03.2025
Titel Quelle:Enthalten in: Knee surgery, sports traumatology, arthroscopy
Ort Quelle:Berlin : Springer, 1993
Jahr Quelle:2024
Band/Heft Quelle:(2024), Seite 1-10
ISSN Quelle:1433-7347
Abstract:Purpose The aim of this study was to evaluate whether additive autologous bone grafting (ABG) improves clinical outcome and survival in revision matrix-associated autologous chondrocyte implantation (M-ACI) after failed cartilage repair (CR). Methods A retrospective, registry-based, matched-pair analysis was performed to compare patient-reported outcomes and survival in secondary M-ACI with or without additional bone grafting for focal full-thickness cartilage defects of the knee and to compare it with those in primary M-ACI. Patients were matched for age, sex, body mass index, defect size and localization, and number of previous CRs. The Knee Injury and Osteoarthritis Outcome Score (KOOS) was assessed over a follow-up period of 36 months. The patient acceptable symptomatic state, the clinical response rate and the survival of the subgroups were determined. Results A total of 818 patients were matched. Revision M-ACI (n = 238) with concomitant bone grafting was associated with significantly higher PRO as measured by KOOS (80.8 ± 16.8 vs. 72.0 ± 17.5, p = 0.032) and higher CRR (81.4% vs. 52.0%, p = 0.018) at 36 months compared to patients with revision M-ACI alone. KOOS and KOOS improvement in these patients did not differ from those who underwent primary M-ACI (p = n.s.). The combination of M-ACI and ABG resulted in a significantly higher KOOS at 36 months than M-ACI alone, regardless of whether bone marrow stimulation (89.6 ± 12.5 vs. 68.1 ± 17.9, p = 0.003) or ACI (82.6 ± 17.0 vs. 72.8 ± 16.0, p = 0.021) was performed before. Additional bone grafting results in equivalent survival rates at 7 years in secondary compared to primary M-ACI (83% vs. 84%, p = n.s.). Conclusions Regardless of the type of previous CR, additional bone grafting in secondary M-ACI improves the clinical outcome, response rate and survival at 36 months compared to M-ACI alone. Secondary M-ACI with ABG had comparable clinical response and survival rates to primary M-ACI. Therefore, subchondral bone should be treated even in cases of mild bone involvement in revision M-ACI. Level of evidence Level III.
DOI:doi:10.1002/ksa.12467
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1002/ksa.12467
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ksa.12467
 DOI: https://doi.org/10.1002/ksa.12467
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cartilage
 clinical study
 knee
 registry
 treatment failure
K10plus-PPN:1919172041
Verknüpfungen:→ Zeitschrift

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