| |  Online-Ressource |
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| Verfasst von: | Leehr, Elisabeth Johanna [VerfasserIn]  |
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| | Brede, Leonie S [VerfasserIn] |
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| | Böhnlein, Joscha [VerfasserIn] |
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| | Roesmann, Kati [VerfasserIn] |
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| | Gathmann, Bettina [VerfasserIn] |
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| | Herrmann, Martin J. [VerfasserIn] |
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| | Junghöfer, Markus [VerfasserIn] |
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| | Schwarzmeier, Hanna [VerfasserIn] |
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| | Seeger, Fabian R. [VerfasserIn] |
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| | Siminski, Niklas [VerfasserIn] |
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| | Straube, Thomas [VerfasserIn] |
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| | Klahn, Anna Luisa [VerfasserIn] |
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| | Weber, Heike Sabine [VerfasserIn] |
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| | Schiele, Miriam A. [VerfasserIn] |
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| | Domschke, Katharina [VerfasserIn] |
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| | Lüken, Ulrike [VerfasserIn] |
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| | Dannlowski, Udo [VerfasserIn] |
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| Titel: | Impact of NPSR1 gene variation on the neural correlates of phasic and sustained fear in spider phobia |
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| Titelzusatz: | an imaging genetics and independent replication approach |
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| Verf.angabe: | Elisabeth J Leehr, Leonie S Brede, Joscha Böhnlein, Kati Roesmann, Bettina Gathmann, Martin J Herrmann, Markus Junghöfer, Hanna Schwarzmeier, Fabian R Seeger, Niklas Siminski, Thomas Straube, Anna Luisa Klahn, Heike Weber, Miriam A Schiele, Katharina Domschke, Ulrike Lueken, Udo Dannlowski |
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| E-Jahr: | 2024 |
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| Jahr: | 21 August 2024 |
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| Umfang: | 11 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 06.03.2025 |
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| Titel Quelle: | Enthalten in: Social cognitive and affective neuroscience |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 2006 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 19(2024), 1, Artikel-ID nsae054, Seite 1-11 |
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| ISSN Quelle: | 1749-5024 |
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| Abstract: | The functional neuropeptide S receptor 1 (NPSR1) gene A/T variant (rs324981) is associated with fear processing. We investigated the impact of NPSR1 genotype on fear processing and on symptom reduction following treatment in individuals with spider phobia. A replication approach was applied [discovery sample: Münster (MS) nMS = 104; replication sample Würzburg (WZ) nWZ = 81]. Participants were genotyped for NPSR1 rs324981 [T-allele carriers (risk) versus AA homozygotes (no-risk)]. A sustained and phasic fear paradigm was applied during functional magnetic resonance imaging. A one-session virtual reality exposure treatment was conducted. Change of symptom severity from pre to post treatment and within session fear reduction were assessed. T-allele carriers in the discovery sample displayed lower anterior cingulate cortex (ACC) activation compared to AA homozygotes independent of condition. For sustained fear, this effect was replicated within a small cluster and medium effect size. No association with symptom reduction was found. Within-session fear reduction was negatively associated with ACC activation in T-allele carriers in the discovery sample. NPSR1 rs324981 genotype might be associated with fear processing in the ACC in spider phobia. Interpretation as potential risk-increasing function of the NPSR1 rs324981 T-allele via impaired top-down control of limbic structures remains speculative. Potential association with symptom reduction warrants further research. |
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| DOI: | doi:10.1093/scan/nsae054 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1093/scan/nsae054 |
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| | kostenfrei: Volltext: https://academic.oup.com/scan/article/19/1/nsae054/7738138?login=true |
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| | DOI: https://doi.org/10.1093/scan/nsae054 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1919260242 |
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| Verknüpfungen: | → Zeitschrift |
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Impact of NPSR1 gene variation on the neural correlates of phasic and sustained fear in spider phobia / Leehr, Elisabeth Johanna [VerfasserIn]; 21 August 2024 (Online-Ressource)
