| |  Online-Ressource |
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| Verfasst von: | Strand, Susanne [VerfasserIn]  |
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| | Hofmann, Walter J. [VerfasserIn] |
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| | Grambihler, Annette [VerfasserIn] |
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| | Hug, Hubert [VerfasserIn] |
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| | Volkmann, Martin [VerfasserIn] |
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| | Otto, Gerd [VerfasserIn] |
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| | Wesch, Horst [VerfasserIn] |
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| | Mariani, Sara M. [VerfasserIn] |
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| | Hack, Volker [VerfasserIn] |
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| | Stremmel, Wolfgang [VerfasserIn] |
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| | Krammer, Peter H. [VerfasserIn] |
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| | Galle, Peter R. [VerfasserIn] |
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| Titel: | Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1 /Fas) Mediated apoptosis |
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| Verf.angabe: | Susanne Strand, Walter J. Hofmann, Annette Grambihler, Hubert Hug, Martin Volkmann, Gerd Otto, Horst Wesch, Sara M. Mariani, Volker Hack, Wolfgang Stremmel, Peter H. Krammer, Peter R. Galle |
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| E-Jahr: | 1998 |
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| Jahr: | 01 May 1998 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 10.03.2025 |
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| Titel Quelle: | Enthalten in: Nature medicine |
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| Ort Quelle: | [New York, NY] : Springer Nature, 1995 |
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| Jahr Quelle: | 1998 |
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| Band/Heft Quelle: | 4(1998), 5, Seite 588-593 |
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| ISSN Quelle: | 1546-170X |
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| Abstract: | Wilson's disease can result in fulminant liver failure due to hepatic copper overload. The CD95 system mediates apoptosis and has been demonstrated to be involved in liver disease. In this study CD95 mediated apoptosis was investigated in patients with fulminant hepatic failure in the course of Wilson's disease and in an in vitro model of copper treated human hepatoma cells. In patients, hepatic expression of CD95 and CD95L mRNA and apoptosis were detected. Copper overload in vitro resulted in hepatocytic apoptosis which could be reduced with a neutralizing anti-CD95L antibody. Copper treatment of hepatocytes results in activation of the CD9S system and induction of apoptosis which is operative during the course of hepatic failure in acute Wilson's disease. |
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| DOI: | doi:10.1038/nm0598-588 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/nm0598-588 |
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| | Volltext: https://www.nature.com/articles/nm0598-588 |
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| | DOI: https://doi.org/10.1038/nm0598-588 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Biomedicine |
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| | Cancer Research |
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| | general |
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| | Infectious Diseases |
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| | Metabolic Diseases |
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| | Molecular Medicine |
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| | Neurosciences |
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| K10plus-PPN: | 1919392742 |
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| Verknüpfungen: | → Zeitschrift |
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Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1 /Fas) Mediated apoptosis / Strand, Susanne [VerfasserIn]; 01 May 1998 (Online-Ressource)
