| |  Online-Ressource |
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| Verfasst von: | Runge, Manuela [VerfasserIn]  |
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| | Karimian, Zahra [VerfasserIn] |
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| | Kheirandish, Mehrnaz [VerfasserIn] |
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| | Borghi, Giulio [VerfasserIn] |
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| | Wodniak, Natalie [VerfasserIn] |
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| | Fahmy, Kamal [VerfasserIn] |
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| | Mantel, Carsten [VerfasserIn] |
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| | Cherian, Thomas [VerfasserIn] |
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| | Nabil Ahmed Said, Zeinab [VerfasserIn] |
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| | Najafi, Farid [VerfasserIn] |
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| | Thneibat, Fatima [VerfasserIn] |
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| | Ul-Haq, Zia [VerfasserIn] |
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| | Fazid, Sheraz [VerfasserIn] |
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| | Ibrahim Salama, Iman [VerfasserIn] |
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| | Khosravi Shadmani, Fatemeh [VerfasserIn] |
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| | Alrawashdeh, Ahmad [VerfasserIn] |
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| | Sirous, Shadrokh [VerfasserIn] |
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| | Bellizzi, Saverio [VerfasserIn] |
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| | Ahmed, Amira [VerfasserIn] |
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| | Lukwiya, Michael [VerfasserIn] |
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| | Rashidian, Arash [VerfasserIn] |
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| Titel: | COVID-19 vaccine effectiveness studies against symptomatic and severe outcomes during the Omicron period in four countries in the Eastern Mediterranean region |
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| Verf.angabe: | Manuela Runge, Zahra Karimian, Mehrnaz Kheirandish, Giulio Borghi, Natalie Wodniak, Kamal Fahmy, Carsten Mantel, Thomas Cherian, Zeinab Nabil Ahmed Said, Farid Najafi, Fatima Thneibat, Zia Ul-Haq, Sheraz Fazid, Iman Ibrahim Salama, Fatemeh Khosravi Shadmani, Ahmad Alrawashdeh, Shadrokh Sirous, Saverio Bellizzi, Amira Ahmed, Michael Lukwiya, Arash Rashidian and on behalf of the consortium of authors |
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| E-Jahr: | 2024 |
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| Jahr: | 10 August 2024 |
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| Umfang: | 16 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 10.03.2025 |
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| Titel Quelle: | Enthalten in: Vaccines |
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| Ort Quelle: | Basel : MDPI, 2013 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 12(2024), 8, Artikel-ID 906, Seite 1-16 |
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| ISSN Quelle: | 2076-393X |
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| Abstract: | Vaccine effectiveness (VE) studies provide real-world evidence to monitor vaccine performance and inform policy. The WHO Regional Office for the Eastern Mediterranean supported a regional study to assess the VE of COVID-19 vaccines against different clinical outcomes in four countries between June 2021 and August 2023. Health worker cohort studies were conducted in 2707 health workers in Egypt and Pakistan, of whom 171 experienced symptomatic laboratory-confirmed SARS-CoV-2 infection. Test-negative design case-control studies were conducted in Iran and Jordan in 4017 severe acute respiratory infection (SARI) patients (2347 controls and 1670 cases) during the Omicron variant dominant period. VE estimates were calculated for each study and pooled by study design for several vaccine types (BBIBP-CorV, AZD1222, BNT162b2, and mRNA-1273, among others). Among health workers, VE against symptomatic infection of a complete primary series could only be computed compared to partial vaccination, suggesting a benefit of providing an additional dose of mRNA vaccines (VE: 88.9%, 95%CI: 15.3-98.6%), while results were inconclusive for other vaccine products. Among SARI patients, VE against hospitalization of a complete primary series with any vaccine compared to non-vaccinated was 20.9% (95%CI: 4.5-34.5%). Effectiveness estimates for individual vaccines, booster doses, and secondary outcomes (intensive care unit admission and death) were inconclusive. Future VE studies will need to address challenges in both design and analysis when conducted late during a pandemic and will be able to utilize the strengthened capacities in countries. |
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| DOI: | doi:10.3390/vaccines12080906 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/vaccines12080906 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2076-393X/12/8/906 |
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| | DOI: https://doi.org/10.3390/vaccines12080906 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | COVID-19 |
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| | eastern Mediterranean region |
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| | Omicron |
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| | SARS-CoV-2 |
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| | vaccine effectiveness |
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| K10plus-PPN: | 191942122X |
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| Verknüpfungen: | → Zeitschrift |
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COVID-19 vaccine effectiveness studies against symptomatic and severe outcomes during the Omicron period in four countries in the Eastern Mediterranean region / Runge, Manuela [VerfasserIn]; 10 August 2024 (Online-Ressource)
