| |  Online-Ressource |
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| Verfasst von: | Watanabe, Masao [VerfasserIn]  |
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| | Leyser, Stephan [VerfasserIn] |
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| | Theysohn, Jens [VerfasserIn] |
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| | Schaarschmidt, Benedikt [VerfasserIn] |
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| | Ludwig, Johannes Maximilian [VerfasserIn] |
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| | Fendler, Wolfgang P. [VerfasserIn] |
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| | Moraitis, Alexandros [VerfasserIn] |
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| | Lahner, Harald [VerfasserIn] |
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| | Mathew, Annie [VerfasserIn] |
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| | Herrmann, Ken [VerfasserIn] |
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| | Weber, Manuel [VerfasserIn] |
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| Titel: | Dose-response relationship in patients with liver metastases from neuroendocrine neoplasms undergoing radioembolization with 90Y glass microspheres |
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| Titelzusatz: | brief communication |
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| Verf.angabe: | Masao Watanabe, Stephan Leyser, Jens Theysohn, Benedikt Schaarschmidt, Johannes Ludwig, Wolfgang P. Fendler, Alexandros Moraitis, Harald Lahner, Annie Mathew, Ken Herrmann, and Manuel Weber |
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| E-Jahr: | 2024 |
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| Jahr: | August 1, 2024 |
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| Umfang: | 6 S. |
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| Fussnoten: | Im Titel ist die Zahl 90 bei "90Y Glass Microspheres" hochgestellt ; Gesehen am 10.03.2025 |
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| Titel Quelle: | Enthalten in: Journal of nuclear medicine |
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| Ort Quelle: | New York, NY : Soc., 1964 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 65(2024), 8 vom: Aug., Seite 1175-1180 |
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| ISSN Quelle: | 2159-662X |
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| | 1535-5667 |
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| Abstract: | The benefit of multicompartment dosimetry in the radioembolization of neuroendocrine neoplasms is not firmly established. We retrospectively assessed its potential with patient outcome. Methods: Forty-three patients were eligible. The association of mean absorbed dose (MAD) for tumors and treatment response was tested per lesion with a receiver operating characteristic curve analysis, and the association of MAD with progression-free survival (PFS) and overall survival was tested per patient using uni- and multivariate Cox regression analyses. Results: The area under the curve for treatment response based on MAD was 0.79 (cutoff, 196.6 Gy; P < 0.0001). For global PFS, grade (grade 2 vs. 1: hazard ratio [HR], 2.51; P = 0.042; grade 3 vs. 1: HR, 62.44; P < 0.001), tumor origin (HR, 6.58; P < 0.001), and MAD (HR, 0.998; P = 0.003) were significant. For overall survival, no prognostic parameters were significant. Conclusion: In line with prior publications, a MAD of more than 200 Gy seemed to favor treatment response. MAD was also associated with PFS and may be of interest for radioembolization planning for neuroendocrine neoplasm patients. |
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| DOI: | doi:10.2967/jnumed.124.267774 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.2967/jnumed.124.267774 |
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| | Volltext: http://jnm.snmjournals.org/content/65/8/1175 |
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| | DOI: https://doi.org/10.2967/jnumed.124.267774 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | multicompartment dosimetry |
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| | neuroendocrine neoplasm |
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| | radioembolization |
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| K10plus-PPN: | 1919440356 |
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| Verknüpfungen: | → Zeitschrift |
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Dose-response relationship in patients with liver metastases from neuroendocrine neoplasms undergoing radioembolization with 90Y glass microspheres / Watanabe, Masao [VerfasserIn]; August 1, 2024 (Online-Ressource)
