The evolving role of dendritic cells in atherosclerosis

• Verfasst von: Britsch, Simone [VerfasserIn]
• Verfasst von: Langer, Harald [VerfasserIn]
• Verfasst von: Dürschmied, Daniel [VerfasserIn]
• Verfasst von: Becher, Tobias [VerfasserIn]
• Titel: The evolving role of dendritic cells in atherosclerosis
• Verf.angabe: Simone Britsch, Harald Langer, Daniel Duerschmied and Tobias Becher
• E-Jahr: 2024
• Jahr: 19 February 2024
• Umfang: 23 S.
• Fussnoten: Gesehen am 11.03.2025 ; Dieser Artikel gehört zum Special issue: Molecular mechanisms and pathophysiology of atherosclerosis 2.0
• Titel Quelle: Enthalten in: International journal of molecular sciences
• Ort Quelle: Basel : Molecular Diversity Preservation International, 2000
• Jahr Quelle: 2024
• Band/Heft Quelle: 25(2024), 4, Artikel-ID 2450, Seite 1-23
• ISSN Quelle: 1422-0067
• ISSN Quelle: 1661-6596
• DOI: doi:10.3390/ijms25042450
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: adaptive immunity
• Sach-SW: atherosclerosis
• Sach-SW: dendritic cells
• Sach-SW: immune cells
• Sach-SW: inflammation
• Sach-SW: innate immunity
• K10plus-PPN: 191948986X

Abstract

Atherosclerosis, a major contributor to cardiovascular morbidity and mortality, is characterized by chronic inflammation of the arterial wall. This inflammatory process is initiated and maintained by both innate and adaptive immunity. Dendritic cells (DCs), which are antigen-presenting cells, play a crucial role in the development of atherosclerosis and consist of various subtypes with distinct functional abilities. Following the recognition and binding of antigens, DCs become potent activators of cellular responses, bridging the innate and adaptive immune systems. The modulation of specific DC subpopulations can have either pro-atherogenic or atheroprotective effects, highlighting the dual pro-inflammatory or tolerogenic roles of DCs. In this work, we provide a comprehensive overview of the evolving roles of DCs and their subtypes in the promotion or limitation of atherosclerosis development. Additionally, we explore antigen pulsing and pharmacological approaches to modulate the function of DCs in the context of atherosclerosis.