| Online-Ressource |
Verfasst von: | Vetter, Sina [VerfasserIn]  |
| Teetzmann, Anton [VerfasserIn]  |
| Baeßler, Joscha [VerfasserIn]  |
| Schreckenberger, Lena [VerfasserIn]  |
| Zaiser, Judith [VerfasserIn]  |
| Pfisterer, Marlen [VerfasserIn]  |
| Stenger, Manuel [VerfasserIn]  |
| Bach, Patrick [VerfasserIn]  |
Titel: | Acute cannabidiol administration reduces alcohol craving and cue-induced nucleus accumbens activation in individuals with alcohol use disorder |
Titelzusatz: | the double-blind randomized controlled ICONIC trial |
Verf.angabe: | Sina Zimmermann, Anton Teetzmann, Joscha Baeßler, Lena Schreckenberger, Judith Zaiser, Marlen Pfisterer, Manuel Stenger and Patrick Bach |
E-Jahr: | 2024 |
Jahr: | 12 December 2024 |
Umfang: | 8 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Online veröffentlicht: 12. Dezember 2024 ; Gesehen am 12.03.2025 |
Titel Quelle: | Enthalten in: Molecular psychiatry |
Ort Quelle: | [London] : Springer Nature, 1997 |
Jahr Quelle: | 2025 |
Band/Heft Quelle: | 30(2025), 6, Seite 2612-2619 |
ISSN Quelle: | 1476-5578 |
Abstract: | Although alcohol use disorder (AUD) is highly prevalent, only a few medications are approved for its treatment leaving much room for improvement. Cannabidiol (CBD) might be a particularly promising candidate, with preclinical data suggesting that CBD is effective in targeting AUD symptoms and disease processes that drive alcohol use and relapse, due to its anti-craving, stress-reducing, and anti-compulsive effects. Here we report data from the double-blind randomized controlled ICONIC trial that compared the effects of a single dose of 800 mg cannabidiol against placebo (PLC) in N = 28 individuals with AUD. Cue-induced nucleus accumbens (NAc) activation, alcohol craving during a combined stress- and alcohol cue exposure session, as well as craving during an fMRI alcohol cue-reactivity task and CBD plasma levels served as outcomes. Individuals receiving CBD showed lower bilateral cue-induced NAc activation (tleft_NAc(23) = 4.906, p < 0.001, d = 1.15; tright_NAc (23) = 4.873, p < 0.001, d = 1.13) and reported significantly lower alcohol craving after a combined stress- and alcohol cue exposure session (Fgroup(1,26) = 4.516, p = 0.043, eta2 = 0.15) and during the fMRI cue-reactivity task (Fgroup(1,24) = 6.665, p = 0.015, eta2 = 0.23). CBD levels were significantly higher in the CBD group (t(25) = 3.808, p < 0.001, d = 1.47) and showed a significant negative association with alcohol craving during the cue exposure experiment (r = −0.394, pFDR = 0.030) and during fMRI (r = −0.389, pFDR = 0.030), and with left and right NAc activation (rleft_NAc = −0.459, pFDR = 0.030; rright_NAc = −0.405, pFDR = 0.030). CBD’s capacity to reduce stress- and cue-induced alcohol craving and to normalize NAc activation - a region critical to the pathophysiology of AUD - contribute to understanding the neurobiological basis of its clinical effects and support its potential as a treatment option for AUD. Clinical Trials Registry: DRKS00029993. |
DOI: | doi:10.1038/s41380-024-02869-y |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41380-024-02869-y |
| kostenfrei: Volltext: https://www.nature.com/articles/s41380-024-02869-y |
| DOI: https://doi.org/10.1038/s41380-024-02869-y |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Addiction |
| Drug discovery |
| Neuroscience |
K10plus-PPN: | 1919617302 |
Verknüpfungen: | → Zeitschrift |
Acute cannabidiol administration reduces alcohol craving and cue-induced nucleus accumbens activation in individuals with alcohol use disorder / Vetter, Sina [VerfasserIn]; 12 December 2024 (Online-Ressource)