| Online-Ressource |
Verfasst von: | Elmajdub, Ahmed [VerfasserIn]  |
| Brebesh, Nahed [VerfasserIn]  |
| Maatough, Annis [VerfasserIn]  |
| Willeke, Frank [VerfasserIn]  |
| Weiß, Christel [VerfasserIn]  |
| Darwich, Ibrahim [VerfasserIn]  |
Titel: | Does indocyanine green fluorescence angiography reduce the risk of anastomotic leaks in colorectal resections? |
Titelzusatz: | A systematic review and meta-analysis of randomized controlled trials |
Verf.angabe: | Ahmed Elmajdub, Nahed Brebesh, Annis Maatough, Frank Willeke, Christel Weiss, Ibrahim Darwich |
Jahr: | 2025 |
Umfang: | 13 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Veröffentlicht: 02. Dezember 2024 ; Gesehen am 12.03.2025 |
Titel Quelle: | Enthalten in: Updates in surgery |
Ort Quelle: | Mailand : Springer Milan, 2010 |
Jahr Quelle: | 2025 |
Band/Heft Quelle: | 77(2025), Seite 83-95 |
ISSN Quelle: | 2038-3312 |
Abstract: | Anastomotic leaks are a significant complication in colorectal surgery. Indocyanine green fluorescence angiography (ICG-FA) has been suggested as a method to reduce the risk. This meta-analysis aims to evaluate the effect of ICG-FA on reducing anastomotic leaks in colorectal surgery. This study follows PRISMA guidelines and is registered on PROSPERO (CRD42022370748). We conducted a comprehensive search of multiple databases and registers for randomized controlled trials (RCTs) comparing ICG-FA with standard methods in colorectal surgery. Data extraction and quality assessment were performed by two independent reviewers, with a third resolving disputes. Odds ratios (OR) and mean differences (MD) were calculated using comprehensive meta-analysis software, version 3. Heterogeneity and publication bias were assessed, and a sensitivity analysis was performed. The analysis included five RCTs with a total of 1369 patients from four countries. The ICG-FA was associated with a 45% reduction in the risk of overall anastomotic leaks (OR: 0.550, p = 0.012). Subgroup analysis showed a 47% reduction in leaks for low anastomoses (OR: 0.53, p = 0.143) and a 69% reduction in grade A leaks (OR: 0.31, p = 0.008). No significant effects were observed for grade B and C leaks, blood loss, surgery duration, hospital stay, mortality, postoperative ileus, reoperation, or surgical site infections. ICG-FA significantly reduces the overall risk of anastomotic leaks, especially grade A leaks, and shows a trend towards fewer leaks in low anastomosis. No significant impact was found on secondary outcomes. Further RCTs are needed to confirm these findings. |
DOI: | doi:10.1007/s13304-024-02036-6 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s13304-024-02036-6 |
| DOI: https://doi.org/10.1007/s13304-024-02036-6 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Anastomotic leak |
| Colectomy |
| Colorectal resection |
| Fluorescence angiography |
| Hemicolectomy |
| Indocyanine green |
K10plus-PPN: | 1919639217 |
Verknüpfungen: | → Zeitschrift |
Does indocyanine green fluorescence angiography reduce the risk of anastomotic leaks in colorectal resections? / Elmajdub, Ahmed [VerfasserIn]; 2025 (Online-Ressource)