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Status: Bibliographieeintrag

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Verfasst von:Elmajdub, Ahmed [VerfasserIn]   i
 Brebesh, Nahed [VerfasserIn]   i
 Maatough, Annis [VerfasserIn]   i
 Willeke, Frank [VerfasserIn]   i
 Weiß, Christel [VerfasserIn]   i
 Darwich, Ibrahim [VerfasserIn]   i
Titel:Does indocyanine green fluorescence angiography reduce the risk of anastomotic leaks in colorectal resections?
Titelzusatz:A systematic review and meta-analysis of randomized controlled trials
Verf.angabe:Ahmed Elmajdub, Nahed Brebesh, Annis Maatough, Frank Willeke, Christel Weiss, Ibrahim Darwich
Jahr:2025
Umfang:13 S.
Illustrationen:Illustrationen
Fussnoten:Veröffentlicht: 02. Dezember 2024 ; Gesehen am 12.03.2025
Titel Quelle:Enthalten in: Updates in surgery
Ort Quelle:Mailand : Springer Milan, 2010
Jahr Quelle:2025
Band/Heft Quelle:77(2025), Seite 83-95
ISSN Quelle:2038-3312
Abstract:Anastomotic leaks are a significant complication in colorectal surgery. Indocyanine green fluorescence angiography (ICG-FA) has been suggested as a method to reduce the risk. This meta-analysis aims to evaluate the effect of ICG-FA on reducing anastomotic leaks in colorectal surgery. This study follows PRISMA guidelines and is registered on PROSPERO (CRD42022370748). We conducted a comprehensive search of multiple databases and registers for randomized controlled trials (RCTs) comparing ICG-FA with standard methods in colorectal surgery. Data extraction and quality assessment were performed by two independent reviewers, with a third resolving disputes. Odds ratios (OR) and mean differences (MD) were calculated using comprehensive meta-analysis software, version 3. Heterogeneity and publication bias were assessed, and a sensitivity analysis was performed. The analysis included five RCTs with a total of 1369 patients from four countries. The ICG-FA was associated with a 45% reduction in the risk of overall anastomotic leaks (OR: 0.550, p = 0.012). Subgroup analysis showed a 47% reduction in leaks for low anastomoses (OR: 0.53, p = 0.143) and a 69% reduction in grade A leaks (OR: 0.31, p = 0.008). No significant effects were observed for grade B and C leaks, blood loss, surgery duration, hospital stay, mortality, postoperative ileus, reoperation, or surgical site infections. ICG-FA significantly reduces the overall risk of anastomotic leaks, especially grade A leaks, and shows a trend towards fewer leaks in low anastomosis. No significant impact was found on secondary outcomes. Further RCTs are needed to confirm these findings.
DOI:doi:10.1007/s13304-024-02036-6
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s13304-024-02036-6
 DOI: https://doi.org/10.1007/s13304-024-02036-6
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Anastomotic leak
 Colectomy
 Colorectal resection
 Fluorescence angiography
 Hemicolectomy
 Indocyanine green
K10plus-PPN:1919639217
Verknüpfungen:→ Zeitschrift

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