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| Verfasst von: | Scholz, Markus [VerfasserIn]  |
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| | Brenner, Hermann [VerfasserIn] |
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| | Delgado Gonzales de Kleber, Graciela [VerfasserIn] |
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| | Holleczek, Bernd [VerfasserIn] |
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| | Jonas, Jost B. [VerfasserIn] |
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| | Kleber, Marcus E. [VerfasserIn] |
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| | Krämer, Bernhard [VerfasserIn] |
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| | März, Winfried [VerfasserIn] |
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| Titel: | X-chromosome and kidney function |
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| Titelzusatz: | evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements |
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| Verf.angabe: | Markus Scholz, Hermann Brenner, Graciela Delgado, Bernd Holleczek, Jost B. Jonas, Marcus E. Kleber, Bernhard K. Krämer, Winfried März [und andere] |
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| E-Jahr: | 2024 |
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| Jahr: | 18 January 2024 |
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| Umfang: | 17 S. |
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| Fussnoten: | Gesehen am 13.03.2025 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 15(2024), 1, Artikel-ID 586, Seite 1-17 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the traits: 7 for uric acid and 16 for estimated glomerular filtration rate (eGFR), including four novel eGFR loci containing the functionally plausible prioritized genes ACSL4, CLDN2, TSPAN6 and the female-specific DRP2. Further, we identified five novel sex-interactions, comprising male-specific effects at FAM9B and AR/EDA2R, and three sex-differential findings with larger genetic effect sizes in males at DCAF12L1 and MST4 and larger effect sizes in females at HPRT1. All prioritized genes in loci showing significant sex-interactions were located next to androgen response elements (ARE). Five ARE genes showed sex-differential expressions. This study contributes new insights into sex-dimorphisms of kidney traits along with new prioritized gene targets for further molecular research. |
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| DOI: | doi:10.1038/s41467-024-44709-1 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41467-024-44709-1 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-024-44709-1 |
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| | DOI: https://doi.org/10.1038/s41467-024-44709-1 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Genetic association study |
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| | Kidney diseases |
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| K10plus-PPN: | 1919692932 |
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| Verknüpfungen: | → Zeitschrift |
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X-chromosome and kidney function / Scholz, Markus [VerfasserIn]; 18 January 2024 (Online-Ressource)
