The Plasmodium circumsporozoite protein

• Verfasst von: Singer, Mirko [VerfasserIn]
• Verfasst von: Kanatani, Sachie [VerfasserIn]
• Verfasst von: Castillo, Stefano Garcia [VerfasserIn]
• Verfasst von: Frischknecht, Friedrich [VerfasserIn]
• Verfasst von: Sinnis, Photini [VerfasserIn]
• Titel: The Plasmodium circumsporozoite protein
• Verf.angabe: Mirko Singer, Sachie Kanatani, Stefano Garcia Castillo, Friedrich Frischknecht, and Photini Sinnis
• E-Jahr: 2024
• Jahr: December 2024
• Umfang: 11 S.
• Illustrationen: Illustrationen
• Fussnoten: Online verfügbar: 20. November 2024, Artikelversion: 4. Dezember 2024 ; Gesehen am 14.03.2025
• Titel Quelle: Enthalten in: Trends in parasitology
• Ort Quelle: Amsterdam : Elsevier, 2001
• Jahr Quelle: 2024
• Band/Heft Quelle: 40(2024), 12 vom: Dez., Seite 1124-1134
• ISSN Quelle: 1471-5007
• DOI: doi:10.1016/j.pt.2024.10.017
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: malaria
• K10plus-PPN: 191977470X

Abstract

The circumsporozoite protein (CSP) is one of the most studied proteins of the malaria parasite. It is the target of the only licensed malaria vaccines and is essential for sporozoite formation and infectivity. Yet, the mechanisms by which CSP functions and its interactions with other proteins are only beginning to be understood. Here we review the current state of knowledge of CSP structure and function, as sporozoites develop in the mosquito and establish infection in the mammalian host, and outline outstanding questions that need to be addressed.