TGF-β drives differentiation of intraepithelial mast cells in inflamed airway mucosa

• Verfasst von: Roers, Axel [VerfasserIn]
• Titel: TGF-β drives differentiation of intraepithelial mast cells in inflamed airway mucosa
• Verf.angabe: Axel Roers
• E-Jahr: 2025
• Jahr: January 2, 2025
• Umfang: 3 S.
• Fussnoten: Gesehen am 18.03.2025
• Titel Quelle: Enthalten in: The journal of clinical investigation
• Ort Quelle: Ann Arbor, Mich. : ASCJ, 1924
• Jahr Quelle: 2025
• Band/Heft Quelle: 135(2025), 1, Artikel-ID e186337, Seite 1-3
• ISSN Quelle: 1558-8238
• DOI: doi:10.1172/JCI186337
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1919992081

Abstract

Similarly to acute intestinal helminth infection, several conditions of chronic eosinophilic type 2 inflammation of mucosal surfaces, including asthma and eosinophilic esophagitis, feature robust expansions of intraepithelial mast cells (MCs). Also the hyperplastic mucosa of nasal polyposis in the context of chronic rhinosinusitis, with or without COX1 inhibitor intolerance, contains impressive numbers of intraepithelial MCs. In this issue of the JCI, Derakhshan et al. elucidate the heterogeneity of MCs in nasal polyposis and identify a transcriptional signature of TGF-β target genes expressed by the intraepithelial MC population. These MCs displayed effector functions that implicate them as pathogenetic contributors. TGF-β directed differentiation of similar MC populations also in vitro. These findings extend the emerging concept of TGF-β as a driver of type 2 inflammation at barrier surfaces.