| Online-Ressource |
Verfasst von: | Pfob, André [VerfasserIn]  |
| Kokh, Daria B. [VerfasserIn]  |
| Surovtsova, Irina [VerfasserIn]  |
| Riedel, Fabian [VerfasserIn]  |
| Morakis, Philipp [VerfasserIn]  |
| Heil, Jörg [VerfasserIn]  |
Titel: | Oncologic outcomes for different axillary staging techniques in patients with nodal-positive breast cancer undergoing neoadjuvant systematic treatment |
Titelzusatz: | a cancer registry study |
Verf.angabe: | André Pfob, MD, Daria B. Kokh, PhD, Irina Surovtsova, PhD, Fabian Riedel, MD, Philipp Morakis, MD, and Joerg Heil, MD |
E-Jahr: | 2024 |
Jahr: | 6 May 2024 |
Umfang: | 12 S. |
Illustrationen: | Diagramme |
Fussnoten: | Gesehen am 18.03.2025 |
Titel Quelle: | Enthalten in: Annals of surgical oncology |
Ort Quelle: | Berlin [u.a.] : Springer, 1994 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 31(2024), 7, Seite 4381-4392 |
ISSN Quelle: | 1534-4681 |
Abstract: | BACKGROUND: Targeted approaches such as targeted axillary dissection (TAD) or sentinel lymph node biopsy (SLNB) showed false-negative rates of < 10% compared with axillary lymph node dissection (ALND) in patients with nodal-positive breast cancer undergoing neoadjuvant systemic treatment (NAST). We aimed to evaluate real-world oncologic outcomes for different axillary staging techniques. - METHODS: We identified nodal-positive breast cancer patients undergoing NAST from 2016 to 2021 from the state cancer registry of Baden-Wuerttemberg, Germany. Invasive disease-free survival (iDFS) was assessed using Kaplan-Meier statistics and multivariate Cox regression models (adjusted for age, ypN stage, ypT stage, and tumor biologic subtype). - RESULTS: A total of 2698 patients with a median follow-up of 24.7 months were identified: 2204 underwent ALND, 460 underwent SLNB (255 with ≥ 3 sentinel lymph nodes [SLNs] removed, 205 with 1-2 SLNs removed), and 34 underwent TAD. iDFS 3 years after surgery was 69.7% (ALND), 76.6% (SLNB with ≥ 3 SLNs removed), 76.7% (SLNB with < 3 SLNs removed), and 78.7% (TAD). Multivariate Cox regression analysis showed no significant influence of different axillary staging techniques on iDFS (hazard ratio [HR] for SLNB with < 3 SLNs removed 0.96, 95% confidence interval [CI] 0.62-1.50; HR for SLNB with ≥ 3 SLNs removed 0.86, 95% CI 0.56-1.3; HR for TAD 0.23, 95% CI 0.03-1.64; ALND reference), and for ypN+ (HR 1.92, 95% CI 1.49-2.49), triple-negative breast cancer (HR 2.35, 95% CI 1.80-3.06), and ypT3-4 (HR 2.93, 95% CI 2.02-4.24). - CONCLUSION: These real-world data provide evidence that patient selection for de-escalated axillary surgery for patients with nodal-positive breast cancer undergoing NAST was successfully adopted and no early alarm signals of iDFS detriment were detected. |
DOI: | doi:10.1245/s10434-024-15292-y |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1245/s10434-024-15292-y |
| DOI: https://doi.org/10.1245/s10434-024-15292-y |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Adult |
| Aged |
| Axilla |
| Axillary staging |
| Breast cancer |
| Breast Neoplasms |
| Cancer registry |
| Female |
| Follow-Up Studies |
| Humans |
| Lymph Node Excision |
| Lymph Nodes |
| Lymphatic Metastasis |
| Middle Aged |
| Neoadjuvant Therapy |
| Neoplasm Staging |
| Nodal positive |
| Prognosis |
| Registries |
| Sentinel Lymph Node Biopsy |
| Survival Rate |
K10plus-PPN: | 1919997199 |
Verknüpfungen: | → Zeitschrift |
Oncologic outcomes for different axillary staging techniques in patients with nodal-positive breast cancer undergoing neoadjuvant systematic treatment / Pfob, André [VerfasserIn]; 6 May 2024 (Online-Ressource)