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Verfasst von:Pfob, André [VerfasserIn]   i
 Kokh, Daria B. [VerfasserIn]   i
 Surovtsova, Irina [VerfasserIn]   i
 Riedel, Fabian [VerfasserIn]   i
 Morakis, Philipp [VerfasserIn]   i
 Heil, Jörg [VerfasserIn]   i
Titel:Oncologic outcomes for different axillary staging techniques in patients with nodal-positive breast cancer undergoing neoadjuvant systematic treatment
Titelzusatz:a cancer registry study
Verf.angabe:André Pfob, MD, Daria B. Kokh, PhD, Irina Surovtsova, PhD, Fabian Riedel, MD, Philipp Morakis, MD, and Joerg Heil, MD
E-Jahr:2024
Jahr:6 May 2024
Umfang:12 S.
Illustrationen:Diagramme
Fussnoten:Gesehen am 18.03.2025
Titel Quelle:Enthalten in: Annals of surgical oncology
Ort Quelle:Berlin [u.a.] : Springer, 1994
Jahr Quelle:2024
Band/Heft Quelle:31(2024), 7, Seite 4381-4392
ISSN Quelle:1534-4681
Abstract:BACKGROUND: Targeted approaches such as targeted axillary dissection (TAD) or sentinel lymph node biopsy (SLNB) showed false-negative rates of < 10% compared with axillary lymph node dissection (ALND) in patients with nodal-positive breast cancer undergoing neoadjuvant systemic treatment (NAST). We aimed to evaluate real-world oncologic outcomes for different axillary staging techniques. - METHODS: We identified nodal-positive breast cancer patients undergoing NAST from 2016 to 2021 from the state cancer registry of Baden-Wuerttemberg, Germany. Invasive disease-free survival (iDFS) was assessed using Kaplan-Meier statistics and multivariate Cox regression models (adjusted for age, ypN stage, ypT stage, and tumor biologic subtype). - RESULTS: A total of 2698 patients with a median follow-up of 24.7 months were identified: 2204 underwent ALND, 460 underwent SLNB (255 with ≥ 3 sentinel lymph nodes [SLNs] removed, 205 with 1-2 SLNs removed), and 34 underwent TAD. iDFS 3 years after surgery was 69.7% (ALND), 76.6% (SLNB with ≥ 3 SLNs removed), 76.7% (SLNB with < 3 SLNs removed), and 78.7% (TAD). Multivariate Cox regression analysis showed no significant influence of different axillary staging techniques on iDFS (hazard ratio [HR] for SLNB with < 3 SLNs removed 0.96, 95% confidence interval [CI] 0.62-1.50; HR for SLNB with ≥ 3 SLNs removed 0.86, 95% CI 0.56-1.3; HR for TAD 0.23, 95% CI 0.03-1.64; ALND reference), and for ypN+ (HR 1.92, 95% CI 1.49-2.49), triple-negative breast cancer (HR 2.35, 95% CI 1.80-3.06), and ypT3-4 (HR 2.93, 95% CI 2.02-4.24). - CONCLUSION: These real-world data provide evidence that patient selection for de-escalated axillary surgery for patients with nodal-positive breast cancer undergoing NAST was successfully adopted and no early alarm signals of iDFS detriment were detected.
DOI:doi:10.1245/s10434-024-15292-y
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1245/s10434-024-15292-y
 DOI: https://doi.org/10.1245/s10434-024-15292-y
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adult
 Aged
 Axilla
 Axillary staging
 Breast cancer
 Breast Neoplasms
 Cancer registry
 Female
 Follow-Up Studies
 Humans
 Lymph Node Excision
 Lymph Nodes
 Lymphatic Metastasis
 Middle Aged
 Neoadjuvant Therapy
 Neoplasm Staging
 Nodal positive
 Prognosis
 Registries
 Sentinel Lymph Node Biopsy
 Survival Rate
K10plus-PPN:1919997199
Verknüpfungen:→ Zeitschrift

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