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| Verfasst von: | Kiss, Eva [VerfasserIn]  |
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| | Kins, Stefan [VerfasserIn] |
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| | Gorgas, Karin [VerfasserIn] |
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| | Venczel Szakács, Kinga Hajnal [VerfasserIn] |
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| | Kirsch, Joachim [VerfasserIn] |
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| | Kuhse, Jochen [VerfasserIn] |
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| Titel: | Another use for a proven drug |
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| Titelzusatz: | experimental evidence for the potential of artemisinin and its derivatives to treat Alzheimer's disease |
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| Verf.angabe: | Eva Kiss, Stefan Kins, Karin Gorgas, Kinga Hajnal Venczel Szakács, Joachim Kirsch and Jochen Kuhse |
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| E-Jahr: | 2024 |
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| Jahr: | 9 April 2024 |
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| Umfang: | 26 S. |
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| Fussnoten: | Gesehen am 18.03.2025 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 25(2024), 8 vom: Apr., Artikel-ID 4165, Seite 1-26 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Plant-derived multitarget compounds may represent a promising therapeutic strategy for multifactorial diseases, such as Alzheimer's disease (AD). Artemisinin and its derivatives were indicated to beneficially modulate various aspects of AD pathology in different AD animal models through the regulation of a wide range of different cellular processes, such as energy homeostasis, apoptosis, proliferation and inflammatory pathways. In this review, we aimed to provide an up-to-date overview of the experimental evidence documenting the neuroprotective activities of artemi-sinins to underscore the potential of these already-approved drugs for treating AD also in humans and propose their consideration for carefully designed clinical trials. In particular, the benefits to the main pathological hallmarks and events in the pathological cascade throughout AD development in different animal models of AD are summarized. Moreover, dose- and context-dependent effects of artemisinins are noted. |
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| DOI: | doi:10.3390/ijms25084165 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/ijms25084165 |
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| | DOI: https://doi.org/10.3390/ijms25084165 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Alzheimer Disease |
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| | Alzheimer’s disease |
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| | Animals |
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| | Apoptosis |
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| | artemisinins |
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| | Artemisinins |
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| | Disease Models, Animal |
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| | Humans |
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| | multitargeting neurotherapeutics |
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| | Neuroprotective Agents |
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| K10plus-PPN: | 1919998918 |
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| Verknüpfungen: | → Zeitschrift |
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Another use for a proven drug / Kiss, Eva [VerfasserIn]; 9 April 2024 (Online-Ressource)
