Circulating extracellular vesicles as biomarkers in the diagnosis, prognosis and therapy of cardiovascular diseases

• Verfasst von: Bernáth-Nagy, Dominika [VerfasserIn]
• Verfasst von: Kalinyaprak, Melek Sükran [VerfasserIn]
• Verfasst von: Giannitsis, Evangelos [VerfasserIn]
• Verfasst von: Ábrahám, Pál [VerfasserIn]
• Verfasst von: Leuschner, Florian [VerfasserIn]
• Verfasst von: Frey, Norbert [VerfasserIn]
• Verfasst von: Krohn, Jona B. [VerfasserIn]
• Titel: Circulating extracellular vesicles as biomarkers in the diagnosis, prognosis and therapy of cardiovascular diseases
• Verf.angabe: Dominika Bernáth-Nagy, Melek Sükran Kalinyaprak, Evangelos Giannitsis, Pál Ábrahám, Florian Leuschner, Norbert Frey and Jona Benjamin Krohn
• E-Jahr: 2024
• Jahr: 02 September 2024
• Umfang: 16 S.
• Fussnoten: Gesehen am 20.03.2025
• Titel Quelle: Enthalten in: Frontiers in Cardiovascular Medicine
• Ort Quelle: Lausanne : Frontiers Media, 2014
• Jahr Quelle: 2024
• Band/Heft Quelle: 11(2024), Artikel-ID 1425159, Seite 1425159-1-1425159-16
• ISSN Quelle: 2297-055X
• DOI: doi:10.3389/fcvm.2024.1425159
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: biomarker6
• Sach-SW: Cardiovascular disease2
• Sach-SW: diagnosis3
• Sach-SW: Extracellular vesicles1
• Sach-SW: Prognosis4
• Sach-SW: therapy5
• K10plus-PPN: 192020394X

Abstract

Cardiovascular disease (CVD) ranks among the primary contributors to worldwide mortality. Hence, the importance of constant research on new circulating biomarkers for the improvement of early diagnosis and prognostication of different CVDs and the development and refinement of therapeutic measures is critical. Extracellular vesicles (EV) have a great potential as diagnostic and prognostic markers, as they represent their parent cell by enclosing cell-specific molecules, which can differ in quality and quantity based on cell state. Assuming that all cell types of the cardiovascular system are capable of releasing EV into circulation, an emerging body of evidence has investigated the potential role of serum- or plasma-derived EV in CVD. Comprehensive research has unveiled alterations in EV quantity and EV-bound cargo in the form of RNA, proteins and lipids in the context of common CVDs such as coronary artery disease, atrial fibrillation, heart failure or inflammatory heart diseases, highlighting their diagnostic and prognostic relevance. In numerous in vitro and in vivo models, EV also showed promising therapeutic potential. However, translation of EV studies to a preclinical or clinical setting has proven to be challenging. This review is intended to provide an overview of the most relevant studies in the field of serum or plasma-derived EV.