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Status: Bibliographieeintrag

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Verfasst von:Wolf, David [VerfasserIn]   i
 Oettl, Lars-Lennart [VerfasserIn]   i
 Winkelmeier, Laurens [VerfasserIn]   i
 Linster, Christiane [VerfasserIn]   i
 Kelsch, Wolfgang [VerfasserIn]   i
Titel:Anterior olfactory cortices differentially transform bottom-up odor signals to produce inverse top-down outputs
Verf.angabe:David Wolf, Lars-Lennart Oettl, Laurens Winkelmeier, Christiane Linster and Wolfgang Kelsch
E-Jahr:2024
Jahr:30 October 2024
Umfang:15 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 24.03.2025
Titel Quelle:Enthalten in: The journal of neuroscience
Ort Quelle:Washington, DC : Soc., 1981
Jahr Quelle:2024
Band/Heft Quelle:44(2024), Artikel-ID 44, Seite 1-15
ISSN Quelle:1529-2401
Abstract:Odor information arrives first in the main olfactory bulb and is then broadcasted to the olfactory cortices and striatum. Downstream regions have unique cellular and connectivity architectures that may generate different coding patterns to the same odors. To reveal region-specific response features, tuning and decoding of single-unit populations, we recorded responses to the same odors under the same conditions across regions, namely, the main olfactory bulb (MOB), the anterior olfactory nucleus (AON), the anterior piriform cortex (aPC), and the olfactory tubercle of the ventral striatum (OT), of awake male mice. We focused on chemically closely related aldehydes that still create distinct percepts. The MOB had the highest decoding accuracy for aldehydes and was the only region encoding chemical similarity. The MOB had the highest fraction of inhibited responses and narrowly tuned odor-excited responses in terms of timing and odor selectivity. Downstream, the interconnected AON and aPC differed in their response patterns to the same stimuli. While odor-excited responses dominated the AON, the aPC had a comparably high fraction of odor-inhibited responses. Both cortices share a main output target that is the MOB. This prompted us to test if the two regions convey also different net outputs. Aldehydes activated AON terminals in the MOB as a bulk signal but inhibited those from the aPC. The differential cortical projection responses generalized to complex odors. In summary, olfactory regions reveal specialized features in their encoding with AON and aPC differing in their local computations, thereby generating inverse net centrifugal and intercortical outputs.
DOI:doi:10.1523/JNEUROSCI.0231-24.2024
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1523/JNEUROSCI.0231-24.2024
 Volltext: https://www.jneurosci.org/content/44/44/e0231242024
 DOI: https://doi.org/10.1523/JNEUROSCI.0231-24.2024
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:centrifugal projections
 inhibition
 olfactory bulb
 piriform cortex
 transformation of odor code
K10plus-PPN:1920394931
Verknüpfungen:→ Zeitschrift

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