Influence of prior myocardial infarction on outcome in patients with ischaemic HFrEF

• Verfasst von: Heer, Tobias [VerfasserIn]
• Verfasst von: Zeymer, Uwe [VerfasserIn]
• Verfasst von: Hochadel, Matthias [VerfasserIn]
• Verfasst von: Frankenstein, Lutz [VerfasserIn]
• Verfasst von: Pauschinger, Matthias [VerfasserIn]
• Verfasst von: Hambrecht, Rainer [VerfasserIn]
• Verfasst von: Bruder, Oliver Helge Willy [VerfasserIn]
• Verfasst von: Böhm, Michael [VerfasserIn]
• Verfasst von: Maier, Lars Siegfried [VerfasserIn]
• Verfasst von: Zahn, Ralf [VerfasserIn]
• Verfasst von: Senges, Jochen [VerfasserIn]
• Titel: Influence of prior myocardial infarction on outcome in patients with ischaemic HFrEF
• Titelzusatz: insights from the EVIdence based TreAtment in Heart Failure (EVITA-HF) registry
• Verf.angabe: Tobias Heer, Uwe Zeymer, Matthias Hochadel, Lutz Frankenstein, Matthias Pauschinger, Rainer Hambrecht, Oliver Bruder, Michael Böhm, Lars S. Maier, Ralf Zahn, Jochen Senges
• E-Jahr: 2024
• Jahr: 8 May 2024
• Umfang: 12 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 24.03.2025
• Titel Quelle: Enthalten in: Clinical research in cardiology
• Ort Quelle: Berlin : Springer, 2006
• Jahr Quelle: 2024
• Band/Heft Quelle: (2024), ahead of print, Seite [1-12]
• ISSN Quelle: 1861-0692
• DOI: doi:10.1007/s00392-024-02455-w
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Health status
• Sach-SW: Ischaemic HFrEF
• Sach-SW: Outcome
• Sach-SW: Prior myocardial infarction
• K10plus-PPN: 1920415882

Abstract

BACKGROUND: There is scarce information about the influence of prior myocardial infarction (pMI) on outcomes in patients (pts) with ischaemic HFrEF. We analysed data from the EVIdence based TreAtment in Heart Failure (EVITA-HF) registry. - METHODS: EVITA-HF comprises web-based case report data on demography, diagnostic measures, adverse events and 1-year follow-up of patients hospitalized for chronic heart failure ≥ 3 months (CHF) and an ejection fraction ≤ 40%. In the present study, we focused on the outcomes of pts with and without pMI in ischaemic HFrEF. - RESULTS: Between February 2009 and November 2015, a total of 2075 consecutive pts with ischaemic HFrEF were included from 16 centres in Germany. A total of 81.2% were male, and the mean age was 71 years. A total of 61.5% of the pts with ischaemic HFrEF had a history of pMI. These pts were treated less often with PCI (20.0 vs. 31.0%, p < 0.001) or CABG (3.8 vs. 7.7%, p < 0.001). They more often received an ICD (40.9 vs. 28.7%, p < 0.001), but less often a CRT-D (11.3 vs. 19.4%, p < 0.001). After multivariate adjustment, pts with pMI had a greater all-cause mortality after 1 year than those without pMI (hazard ratio 1.4; 95% CI, 1.10-1.79, p = 0.007). The combined endpoint of death, resuscitation or ICD shock after 1 year was greater in patients with pMI (20.8 vs. 16.4%, p = 0.03). Mobility was more often reduced in pts with pMI (46.8% vs. 40.1%, p = 0.03), and overall health status was more frequently worse in patients with pMI than in those 12 months ago (23.1 vs. 15.9%, p = 0.01). More than a quarter of the pts with ischaemic HFrEF were anxious or depressive. - CONCLUSION: pMI in patients with CHF and ischaemic HFrEF was associated with increased mortality, increased event rates, and worsened health status. Hence, the subgroup of pts with ischaemic HFrEF and pMI is at higher risk and deserves special attention.