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Titel:Medullary thyroid carcinoma
Titelzusatz:biology, management, and treatment of sporadic and hereditary MTC
Mitwirkende:Raue, Friedhelm [HerausgeberIn]   i
 Frank-Raue, Karin [HerausgeberIn]   i
Verf.angabe:edited by Friedhelm Raue, Karin Frank-Raue
Ausgabe:2nd ed. 2025.
Verlagsort:Cham
 Cham
Verlag:Springer Nature Switzerland
 Imprint: Springer
E-Jahr:2025
Jahr:2025.
 2025.
Umfang:1 Online-Ressource (XVI, 307 p. 48 illus., 30 illus. in color.)
Gesamttitel/Reihe:Recent Results in Cancer Research ; 223
ISBN:978-3-031-80396-3
Abstract:What is new? -- Thyroid C-Cell Biology and Oncogenic Transformation -- Histopathology of C cells and medullary thyroid carcinoma -- Epidemiology and clinical presentation of Medullary Thyroid Carcinoma -- Medullary thyroid carcinoma: Imaging -- Calcitonin as a Biomarker for Medullary Thyroid Carcinoma -- Hereditary Medullary Thyroid Cancer, Genotype phenotype correlation -- Pheochromocytomas in Multiple Endocrine Neoplasia type 2 -- Primary hyperparathyroidism in Multiple Endocrine Neoplasia 2 Syndrome -- Surgical treatment of medullary thyroid carcinoma -- Long term follow up in medullary thyroid carcinoma -- Use of Tyrosine Kinase Inhibitors for Treatment of Medullary Thyroid Carcinoma.
 After 10 years, this second edition is extensively rewritten and updated and provides a source of information concerning all aspects of medullary thyroid carcinoma, including comprehensive actual references for interested scientists. Medullary thyroid carcinoma (MTC) is a rare unique tumor which differs from other thyroid tumors by originating from the neuroendocrine C-cell, secreting the specific tumor marker calcitonin. MTC is associated in about 25% of cases with multiple endocrine neoplasia type 2, an autosomal dominant familial disorder causing tumors within various endocrine glands. The molecular genetics of tumor development is clarified: hereditary as well as sporadic MTC are linked to mutations in the RET proto- oncogene coding for a tyrosine kinase. These RET mutations serve as a genetic marker for hereditary MTC and allow for prophylactic thyroidectomy in gene carriers. The RET-tyrosine kinase is also a new therapeutic target using selective tyrosine kinase inhibitors improving the outcome of advanced metastasized MTC. This book will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.
DOI:doi:10.1007/978-3-031-80396-3
URL:Resolving-System: https://doi.org/10.1007/978-3-031-80396-3
 DOI: https://doi.org/10.1007/978-3-031-80396-3
Datenträger:Online-Ressource
Sprache:eng
Bibliogr. Hinweis:Erscheint auch als : Druck-Ausgabe
 Erscheint auch als : Druck-Ausgabe
 Erscheint auch als : Druck-Ausgabe
K10plus-PPN:192050303X
 
 
Lokale URL UB: Zum Volltext
 
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