| Online-Ressource |
Titel: | Medullary thyroid carcinoma |
Titelzusatz: | biology, management, and treatment of sporadic and hereditary MTC |
Mitwirkende: | Raue, Friedhelm [HerausgeberIn]  |
| Frank-Raue, Karin [HerausgeberIn]  |
Verf.angabe: | edited by Friedhelm Raue, Karin Frank-Raue |
Ausgabe: | 2nd ed. 2025. |
Verlagsort: | Cham |
| Cham |
Verlag: | Springer Nature Switzerland |
| Imprint: Springer |
E-Jahr: | 2025 |
Jahr: | 2025. |
| 2025. |
Umfang: | 1 Online-Ressource (XVI, 307 p. 48 illus., 30 illus. in color.) |
Gesamttitel/Reihe: | Recent Results in Cancer Research ; 223 |
ISBN: | 978-3-031-80396-3 |
Abstract: | What is new? -- Thyroid C-Cell Biology and Oncogenic Transformation -- Histopathology of C cells and medullary thyroid carcinoma -- Epidemiology and clinical presentation of Medullary Thyroid Carcinoma -- Medullary thyroid carcinoma: Imaging -- Calcitonin as a Biomarker for Medullary Thyroid Carcinoma -- Hereditary Medullary Thyroid Cancer, Genotype phenotype correlation -- Pheochromocytomas in Multiple Endocrine Neoplasia type 2 -- Primary hyperparathyroidism in Multiple Endocrine Neoplasia 2 Syndrome -- Surgical treatment of medullary thyroid carcinoma -- Long term follow up in medullary thyroid carcinoma -- Use of Tyrosine Kinase Inhibitors for Treatment of Medullary Thyroid Carcinoma. |
| After 10 years, this second edition is extensively rewritten and updated and provides a source of information concerning all aspects of medullary thyroid carcinoma, including comprehensive actual references for interested scientists. Medullary thyroid carcinoma (MTC) is a rare unique tumor which differs from other thyroid tumors by originating from the neuroendocrine C-cell, secreting the specific tumor marker calcitonin. MTC is associated in about 25% of cases with multiple endocrine neoplasia type 2, an autosomal dominant familial disorder causing tumors within various endocrine glands. The molecular genetics of tumor development is clarified: hereditary as well as sporadic MTC are linked to mutations in the RET proto- oncogene coding for a tyrosine kinase. These RET mutations serve as a genetic marker for hereditary MTC and allow for prophylactic thyroidectomy in gene carriers. The RET-tyrosine kinase is also a new therapeutic target using selective tyrosine kinase inhibitors improving the outcome of advanced metastasized MTC. This book will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians. |
DOI: | doi:10.1007/978-3-031-80396-3 |
URL: | Resolving-System: https://doi.org/10.1007/978-3-031-80396-3 |
| DOI: https://doi.org/10.1007/978-3-031-80396-3 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe |
| Erscheint auch als : Druck-Ausgabe |
| Erscheint auch als : Druck-Ausgabe |
K10plus-PPN: | 192050303X |
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Lokale URL UB: | Zum Volltext |
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| Bibliothek der Medizinischen Fakultät Mannheim der Universität Heidelberg |
| Bestellen/Vormerken für Benutzer des Klinikums Mannheim Eigene Kennung erforderlich |
Bibliothek/Idn: | UW / m4692501340 |
Lokale URL Inst.: | Zum Volltext |
Medullary thyroid carcinoma / Raue, Friedhelm [HerausgeberIn]; 2025. (Online-Ressource)