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| Verfasst von: | Russo, Eleonora [VerfasserIn]  |
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| | Becker, Nadine [VerfasserIn] |
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| | Domanski, Aleks P. F. [VerfasserIn] |
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| | Howe, Timothy [VerfasserIn] |
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| | Freud, Kipp [VerfasserIn] |
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| | Durstewitz, Daniel [VerfasserIn] |
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| | Jones, Matthew W. [VerfasserIn] |
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| Titel: | Integration of rate and phase codes by hippocampal cell-assemblies supports flexible encoding of spatiotemporal context |
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| Verf.angabe: | Eleonora Russo, Nadine Becker, Aleks P. F. Domanski, Timothy Howe, Kipp Freud, Daniel Durstewitz & Matthew W. Jones |
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| E-Jahr: | 2024 |
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| Jahr: | 22 October 2024 |
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| Umfang: | 17 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 26.03.2025 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 15(2024), Artikel-ID 8880, Seite 1-17 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Spatial information is encoded by location-dependent hippocampal place cell firing rates and sub-second, rhythmic entrainment of spike times. These rate and temporal codes have primarily been characterized in low-dimensional environments under limited cognitive demands; but how is coding configured in complex environments when individual place cells signal several locations, individual locations contribute to multiple routes and functional demands vary? Quantifying CA1 population dynamics of male rats during a decision-making task, here we show that the phase of individual place cells’ spikes relative to the local theta rhythm shifts to differentiate activity in different place fields. Theta phase coding also disambiguates repeated visits to the same location during different routes, particularly preceding spatial decisions. Using unsupervised detection of cell assemblies alongside theoretical simulation, we show that integrating rate and phase coding mechanisms dynamically recruits units to different assemblies, generating spiking sequences that disambiguate episodes of experience and multiplexing spatial information with cognitive context. |
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| DOI: | doi:10.1038/s41467-024-52988-x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41467-024-52988-x |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-024-52988-x |
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| | DOI: https://doi.org/10.1038/s41467-024-52988-x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Hippocampus |
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| | Neural encoding |
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| | Spatial memory |
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| K10plus-PPN: | 1920620303 |
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| Verknüpfungen: | → Zeitschrift |
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Integration of rate and phase codes by hippocampal cell-assemblies supports flexible encoding of spatiotemporal context / Russo, Eleonora [VerfasserIn]; 22 October 2024 (Online-Ressource)
