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| Verfasst von: | Conzelmann, Nina [VerfasserIn]  |
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| | Benimeli Borràs, Ariadna [VerfasserIn] |
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| | Muduli, Saradaprasan [VerfasserIn] |
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| | Schramm, Anastassiya [VerfasserIn] |
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| | Jeschenko, Pascal Max [VerfasserIn] |
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| | Platzman, Ilia [VerfasserIn] |
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| | Spatz, Joachim P. [VerfasserIn] |
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| Titel: | Modular porous polymer-based microcapsules for trapping and near-infrared light-triggered killing of bacteria via gold nanorods |
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| Verf.angabe: | Nina F. Conzelmann, Ariadna Benimeli Borràs, Saradaprasan Muduli, Anastassiya Schramm, Pascal M. Jeschenko, Ilia Platzman and Joachim P. Spatz |
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| E-Jahr: | 2024 |
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| Jahr: | September 23, 2024 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 27.03.2025 |
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| Titel Quelle: | Enthalten in: ACS applied nano materials |
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| Ort Quelle: | Washington, DC : ACS Publications, 2018 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 7(2024), 19, Seite 22650-22661 |
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| ISSN Quelle: | 2574-0970 |
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| Abstract: | Due to the increasing occurrence of antibiotic-resistant bacterial strains worldwide, there is an urgent need for developing antibiotic-independent strategies to combat bacterial infections. In this study, we developed a modular approach for trapping, retaining, and killing bacteria by means of porous, poly(lactic-co-glycolic acid) (PLGA)-based microcapsules with integrated gold nanorods (AuNRs). AuNRs were coated with thiol-functionalized PLGA beforehand to ensure efficient integration into the hydrophobic microcapsule shells. For the efficient generation of AuNR-functionalized microcapsules, we designed and developed a fast and reliable one-pot bulk emulsification production method. When exposing the AuNR-decorated microcapsules to near-infrared light, both motile and nonmotile bacteria were killed in a highly localized manner due to AuNR-generated heat. Importantly, fibroblast cell viability tests performed with AuNR-decorated microcapsules revealed good biocompatibility of the system. Such a modular antibacterial system can be employed in various applications, including, but not limited to, implant coatings, flushing solutions, and sewage treatment. |
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| DOI: | doi:10.1021/acsanm.4c03636 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1021/acsanm.4c03636 |
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| | DOI: https://doi.org/10.1021/acsanm.4c03636 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1920730230 |
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| Verknüpfungen: | → Zeitschrift |
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Modular porous polymer-based microcapsules for trapping and near-infrared light-triggered killing of bacteria via gold nanorods / Conzelmann, Nina [VerfasserIn]; September 23, 2024 (Online-Ressource)
