| Online-Ressource |
Verfasst von: | Conzelmann, Nina [VerfasserIn]  |
| Benimeli Borràs, Ariadna [VerfasserIn]  |
| Muduli, Saradaprasan [VerfasserIn]  |
| Schramm, Anastassiya [VerfasserIn]  |
| Jeschenko, Pascal Max [VerfasserIn]  |
| Platzman, Ilia [VerfasserIn]  |
| Spatz, Joachim P. [VerfasserIn]  |
Titel: | Modular porous polymer-based microcapsules for trapping and near-infrared light-triggered killing of bacteria via gold nanorods |
Verf.angabe: | Nina F. Conzelmann, Ariadna Benimeli Borràs, Saradaprasan Muduli, Anastassiya Schramm, Pascal M. Jeschenko, Ilia Platzman and Joachim P. Spatz |
E-Jahr: | 2024 |
Jahr: | September 23, 2024 |
Umfang: | 12 S. |
Fussnoten: | Gesehen am 27.03.2025 |
Titel Quelle: | Enthalten in: ACS applied nano materials |
Ort Quelle: | Washington, DC : ACS Publications, 2018 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 7(2024), 19, Seite 22650-22661 |
ISSN Quelle: | 2574-0970 |
Abstract: | Due to the increasing occurrence of antibiotic-resistant bacterial strains worldwide, there is an urgent need for developing antibiotic-independent strategies to combat bacterial infections. In this study, we developed a modular approach for trapping, retaining, and killing bacteria by means of porous, poly(lactic-co-glycolic acid) (PLGA)-based microcapsules with integrated gold nanorods (AuNRs). AuNRs were coated with thiol-functionalized PLGA beforehand to ensure efficient integration into the hydrophobic microcapsule shells. For the efficient generation of AuNR-functionalized microcapsules, we designed and developed a fast and reliable one-pot bulk emulsification production method. When exposing the AuNR-decorated microcapsules to near-infrared light, both motile and nonmotile bacteria were killed in a highly localized manner due to AuNR-generated heat. Importantly, fibroblast cell viability tests performed with AuNR-decorated microcapsules revealed good biocompatibility of the system. Such a modular antibacterial system can be employed in various applications, including, but not limited to, implant coatings, flushing solutions, and sewage treatment. |
DOI: | doi:10.1021/acsanm.4c03636 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1021/acsanm.4c03636 |
| DOI: https://doi.org/10.1021/acsanm.4c03636 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1920730230 |
Verknüpfungen: | → Zeitschrift |
Modular porous polymer-based microcapsules for trapping and near-infrared light-triggered killing of bacteria via gold nanorods / Conzelmann, Nina [VerfasserIn]; September 23, 2024 (Online-Ressource)