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| Verfasst von: | Kalev, Georgi [VerfasserIn]  |
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| | Büttner, Sylvia [VerfasserIn] |
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| | Zhan, Tianzuo [VerfasserIn] |
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| | Hofheinz, Ralf-Dieter [VerfasserIn] |
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| | Boda-Heggemann, Judit [VerfasserIn] |
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| | Reißfelder, Christoph [VerfasserIn] |
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| | Seyfried, Steffen [VerfasserIn] |
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| | Vassilev, Georgi [VerfasserIn] |
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| | Hardt, Julia [VerfasserIn] |
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| Titel: | Watch-and-wait approach following neoadjuvant chemo-radiotherapy for locally advanced rectal cancer |
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| Titelzusatz: | a retrospective single-center cohort study |
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| Verf.angabe: | Georgi Kalev, Sylvia Buettner, Tianzuo Zhan, Ralf-Dieter Hofheinz, Judit Boda-Heggemann, Christoph Reissfelder, Steffen Seyfried, Georgi Vassilev, Julia Hardt |
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| E-Jahr: | 2024 |
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| Jahr: | 14 November 2024 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 31.03.2025 |
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| Titel Quelle: | Enthalten in: Journal of surgical oncology |
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| Ort Quelle: | Bognor Regis [u.a.] : Wiley, 1996 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | (2024), Seite 1-7 |
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| ISSN Quelle: | 1096-9098 |
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| Abstract: | Background and Objectives The watch-and-wait (WW) strategy in patients after complete clinical response (cCR) following chemoradiotherapy for locally advanced rectal cancer (LARC) offers the option of organ preservation. The aim of this study was to assess the oncological outcomes of WW patients treated and followed up in a German referral cancer center. Methods In this retrospective study, we analyzed the clinical records of consecutive patients with LARC who underwent neoadjuvant radiotherapy/chemoradiotherapy at our institution between January 2020 and December 2023 and received non-operative management after cCR. Results A total of 30 patients undergoing WW for LARC were included. After a median follow-up of 17 months (SD = 10 months), local regrowth occurred in four patients (4/30, 13.3%), and one patient (1/30, 3.3%) developed distant metastasis. No predictor for tumor regrowth could be identified based on radiological findings at diagnosis, including cT4 and/or cN2, involvement of the mesorectal fascia, extramural vascular invasion or infiltration of the anal sphincter/levator. All patients with local regrowth were successfully surgically treated (R0 resection). Conclusion Nonoperative management for patients with cCR after neoadjuvant therapy for LARC proved to be safe. R0 resection was successfully achieved in all patients who underwent salvage surgery. |
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| DOI: | doi:10.1002/jso.28001 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/jso.28001 |
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| | kostenfrei: Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1002/jso.28001 |
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| | DOI: https://doi.org/10.1002/jso.28001 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | neoadjuvant therapy |
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| | nonoperative management |
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| | rectal cancer |
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| | watch and wait |
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| K10plus-PPN: | 1920865608 |
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| Verknüpfungen: | → Zeitschrift |
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Watch-and-wait approach following neoadjuvant chemo-radiotherapy for locally advanced rectal cancer / Kalev, Georgi [VerfasserIn]; 14 November 2024 (Online-Ressource)
