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Verfasst von:Stahl, Mirjam [VerfasserIn]   i
 Joachim, Cornelia [VerfasserIn]   i
 Kirsch, Ines [VerfasserIn]   i
 Uselmann, Tatjana [VerfasserIn]   i
 Yu, Yin [VerfasserIn]   i
 Alfeis, Nadine [VerfasserIn]   i
 Berger, Christiane [VerfasserIn]   i
 Minso, Rebecca [VerfasserIn]   i
 Rudolf, Isa [VerfasserIn]   i
 Stolpe, Cornelia [VerfasserIn]   i
 Bovermann, Xenia [VerfasserIn]   i
 Liboschik, Lena [VerfasserIn]   i
 Steinmetz, Alena [VerfasserIn]   i
 Tennhardt, Dunja [VerfasserIn]   i
 Dörfler, Friederike [VerfasserIn]   i
 Röhmel, Jobst [VerfasserIn]   i
 Unorji-Frank, Klaudia [VerfasserIn]   i
 Rückes-Nilges, Claudia [VerfasserIn]   i
 Stoutz, Bianca von [VerfasserIn]   i
 Naehrlich, Lutz [VerfasserIn]   i
 Kopp, Matthias V. [VerfasserIn]   i
 Dittrich, Anna-Maria [VerfasserIn]   i
 Sommerburg, Olaf [VerfasserIn]   i
 Mall, Marcus A. [VerfasserIn]   i
Titel:Multicentre feasibility of multiple-breath washout in preschool children with cystic fibrosis and other lung diseases
Verf.angabe:Mirjam Stahl, Cornelia Joachim, Ines Kirsch, Tatjana Uselmann, Yin Yu, Nadine Alfeis, Christiane Berger, Rebecca Minso, Isa Rudolf, Cornelia Stolpe, Xenia Bovermann, Lena Liboschik, Alena Steinmetz, Dunja Tennhardt, Friederike Dörfler, Jobst Röhmel, Klaudia Unorji-Frank, Claudia Rückes-Nilges, Bianca von Stoutz, Lutz Naehrlich, Matthias V. Kopp, Anna-Maria Dittrich, Olaf Sommerburg and Marcus A. Mall
Jahr:2020
Umfang:11 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 31.03.2025
Titel Quelle:Enthalten in: ERJ Open Research
Ort Quelle:[Erscheinungsort nicht ermittelbar] : European Respiratory Society, 2015
Jahr Quelle:2020
Band/Heft Quelle:6(2020), 4, Artikel-ID 00408-2020, Seite 1-11
ISSN Quelle:2312-0541
Abstract:<sec><title>Background</title><p>Multiple-breath washout (MBW)-derived lung clearance index (LCI) detects early cystic fibrosis (CF) lung disease. LCI was used as an end-point in single- and multicentre settings at highly experienced MBW centres in preschool children. However, multicentre feasibility of MBW in children aged 2-6 years, including centres naïve to this technique, has not been determined systematically.</p></sec><sec><title>Methods</title><p>Following central training, 91 standardised nitrogen MBW investigations were performed in 74 awake preschool children (15 controls, 46 with CF, and 13 with other lung diseases), mean age 4.6±0.9 years at investigation, using a commercially available device across five centres in Germany (three experienced, two naïve to the performance in awake preschool children) with central data analysis. Each MBW investigation consisted of several measurements.</p></sec><sec><title>Results</title><p>Overall success rate of MBW investigations was 82.4% ranging from 70.6% to 94.1% across study sites. The number of measurements per investigation was significantly different between sites ranging from 3.7 to 6.2 (p<0.01), while the mean number of successful measurements per investigation was comparable with 2.1 (range, 1.9 to 2.5; p=0.46). In children with CF, the LCI was increased (median 8.2, range, 6.7-15.5) compared to controls (median 7.3, range 6.5-8.3; p<0.01), and comparable to children with other lung diseases (median 7.9, range, 6.6-13.9; p=0.95).</p></sec><sec><title>Conclusion</title><p>This study demonstrates that multicentre MBW in awake preschool children is feasible, even in centres previously naïve, with central coordination to assure standardised training, quality control and supervision. Our results support the use of LCI as multicentre end-point in clinical trials in awake preschoolers with CF.</p></sec>
DOI:doi:10.1183/23120541.00408-2020
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1183/23120541.00408-2020
 kostenfrei: Volltext: https://publications.ersnet.org/content/erjor/6/4/00408-2020
 DOI: https://doi.org/10.1183/23120541.00408-2020
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1920887091
Verknüpfungen:→ Zeitschrift

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