Age variation in patients with troponin level elevation without obstructive culprit lesion or suspected myocardial infarction with non-obstructive Coronary arteries

• Verfasst von: Abumayyaleh, Mohammad S. A. [VerfasserIn]
• Verfasst von: Schlettert, Clara [VerfasserIn]
• Verfasst von: Materzok, Daniel [VerfasserIn]
• Verfasst von: Mügge, Andreas [VerfasserIn]
• Verfasst von: Hamdani, Nazha [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Verfasst von: Aweimer, Assem [VerfasserIn]
• Verfasst von: El-Battrawy, Ibrahim [VerfasserIn]
• Titel: Age variation in patients with troponin level elevation without obstructive culprit lesion or suspected myocardial infarction with non-obstructive Coronary arteries
• Titelzusatz: long-term data covering over decade
• Verf.angabe: Mohammad Abumayyaleh, Clara Schlettert, Daniel Materzok, Andreas Mügge, Nazha Hamdani, Ibrahim Akin, Assem Aweimer and Ibrahim El-Battrawy
• E-Jahr: 2024
• Jahr: 17 December 2024
• Umfang: 12 S.
• Fussnoten: Gesehen am 03.04.2025
• Titel Quelle: Enthalten in: Journal of Clinical Medicine
• Ort Quelle: Basel : MDPI, 2012
• Jahr Quelle: 2024
• Band/Heft Quelle: 13(2024), 24, Artikel-ID 7685, Seite 1-12
• ISSN Quelle: 2077-0383
• DOI: doi:10.3390/jcm13247685
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: age
• Sach-SW: arrhythmias
• Sach-SW: atrial fibrillation
• Sach-SW: cardiovascular mortality
• Sach-SW: MINOCA
• Sach-SW: myocardial infarction
• K10plus-PPN: 1921334487

Abstract

Background/Objectives: Troponin level elevation without an obstructive culprit lesion is caused by heterogenous entities. The effect of aging on this condition has been poorly investigated. Methods: After screening 24,775 patients between 2010 and 2021, this study included a total of 373 patients with elevated troponin levels without an obstructive culprit lesion or suspected myocardial infarction with non-obstructive coronary arteries (MINOCAs) categorized into four age groups containing 78 patients (<51 years), 72 patients (51-60 years), 81 patients (61-70 years), and 142 patients (>70 years). This study analyzed the baseline characteristics, the in-hospital complications, in-hospital mortality, and the long-term outcomes. Results: The older patients exhibited a higher rate of major adverse cardiovascular in-hospital events than those of the other age groups (15.4% in the <51-year-old group vs. 36.1% in the 51-60-year-old group vs. 33.3% in the 61-70-year-old group vs. 47.2% in the >70-year-old group; p < 0.001). However, the rate of non-sustained ventricular tachycardia (nsVT) was higher in the 51-60-year-old patients than those of the other age groups (5.6% in the 51-60-year-old group vs. 1.3% in the 61-70-year-old group vs. 0.7% in the >70-year-old group; p = 0.027). At the 11-year follow-up, cardiovascular mortality was higher among the older patients compared to that of the younger patients (3.9% in the 61-70-year-old group vs. 4.2% in the >70-year-old group, p = 0.042), while non-cardiovascular mortality was comparable between the age groups. Conclusions: The older patients with troponin level elevation without an obstructive culprit lesion experienced a higher incidence of major adverse cardiovascular events during hospitalization compared to that of the younger groups. Additionally, higher cardiovascular mortality rates were revealed in the older patients at a long-term follow-up.