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| Verfasst von: | Seum, Teresa [VerfasserIn]  |
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| | Frick, Clara [VerfasserIn] |
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| | Cardoso, Rafael [VerfasserIn] |
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| | Bhardwaj, Megha [VerfasserIn] |
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| | Hoffmeister, Michael [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| Titel: | Potential of pre-diagnostic metabolomics for colorectal cancer risk assessment or early detection |
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| Verf.angabe: | Teresa Seum, Clara Frick, Rafael Cardoso, Megha Bhardwaj, Michael Hoffmeister & Hermann Brenner |
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| E-Jahr: | 2024 |
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| Jahr: | 27 October 2024 |
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| Umfang: | 13 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 04.04.2025 |
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| Titel Quelle: | Enthalten in: npj precision oncology |
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| Ort Quelle: | [London] : Springer Nature, 2017 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 8(2024), Artikel-ID 244, Seite 1-13 |
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| ISSN Quelle: | 2397-768X |
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| Abstract: | This systematic review investigates the efficacy of metabolite biomarkers for risk assessment or early detection of colorectal cancer (CRC) and its precursors, focusing on pre-diagnostic biospecimens. Searches in PubMed, Web of Science, and SCOPUS through December 2023 identified relevant prospective studies. Relevant data were extracted, and the risk of bias was assessed with the QUADAS-2 tool. Among the 26 studies included, significant heterogeneity existed for case numbers, metabolite identification, and validation approaches. Thirteen studies evaluated individual metabolites, mainly lipids, while eleven studies derived metabolite panels, and two studies did both. Nine panels were internally validated, resulting in an area under the curve (AUC) ranging from 0.69 to 0.95 for CRC precursors and 0.72 to 1.0 for CRC. External validation was limited to one panel (AUC = 0.72). Metabolite panels and lipid-based biomarkers show promise for CRC risk assessment and early detection but require standardization and extensive validation for clinical use. |
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| DOI: | doi:10.1038/s41698-024-00732-5 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41698-024-00732-5 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41698-024-00732-5 |
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| | DOI: https://doi.org/10.1038/s41698-024-00732-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer screening |
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| | Predictive markers |
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| | Risk factors |
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| K10plus-PPN: | 1921426403 |
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| Verknüpfungen: | → Zeitschrift |
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Potential of pre-diagnostic metabolomics for colorectal cancer risk assessment or early detection / Seum, Teresa [VerfasserIn]; 27 October 2024 (Online-Ressource)
