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Status: Bibliographieeintrag

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Verfasst von:Dietz-Ziegler, Stefanie [VerfasserIn]   i
 Hebel, Janine [VerfasserIn]   i
 Rühle, Jessica [VerfasserIn]   i
 Huff, Alisha [VerfasserIn]   i
 Eltzschig, Holger K. [VerfasserIn]   i
 Lajqi, Trim [VerfasserIn]   i
 Poets, Christian F. [VerfasserIn]   i
 Gille, Christian [VerfasserIn]   i
 Köstlin-Gille, Natascha [VerfasserIn]   i
Titel:Impact of the adenosine receptor A2BR expressed on myeloid cells on immune regulation during pregnancy
Verf.angabe:Stefanie Dietz, Janine Hebel, Jessica Rühle, Alisha Huff, Holger K. Eltzschig, Trim Lajqi, Christian F. Poets, Christian Gille and Natascha Köstlin-Gille
E-Jahr:2024
Jahr:December 2024
Umfang:14 S.
Illustrationen:Illustrationen
Fussnoten:Veröffentlicht: 25 October 2024 ; Gesehen am 07.04.2025
Titel Quelle:Enthalten in: European journal of immunology
Ort Quelle:Weinheim : Wiley-VCH, 1971
Jahr Quelle:2024
Band/Heft Quelle:54(2024), 12 vom: Dez., Artikel-ID 2451149, Seite 1-14
ISSN Quelle:1521-4141
Abstract:During pregnancy, the maternal immune system must carefully balance protection against pathogens with tolerance toward the semiallogeneic fetus. Dysfunctions of the immune system can lead to severe complications such as preeclampsia, fetal growth restriction, or pregnancy loss. Adenosine plays a role in physiological processes and plasma-level increase during pregnancy. The adenosine receptor A2B (A2BR), which is expressed on both, immune and nonimmune cells, is activated by high adenosine concentrations, achieved during pregnancy. We investigated the impact of A2BR expressed on myeloid cells on immune regulation during pregnancy using a mouse model with myeloid deficiency for A2BR. We demonstrate systemic changes in myeloid and lymphoid cell populations during pregnancy in A2BR-KO (Adora2B923f/f-LysMCre) mice with increased monocytes, neutrophils, and T cells but decreased B cells as well as altered T-cell subpopulations with decreased Th1 cells and Tregs and increased Th17 cells. Lack of A2BR on myeloid cells caused an increased systemic expression of IL-6 but decreased systemic accumulation and function of MDSC and reduced numbers of uterine natural killer cells. The pregnancy outcome was only marginally affected. Our results demonstrate that A2BR on myeloid cells plays a role in immune regulation during pregnancy, but the clinical impact on pregnancy remains unclear.
DOI:doi:10.1002/eji.202451149
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1002/eji.202451149
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202451149
 DOI: https://doi.org/10.1002/eji.202451149
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adenosine receptor
 Immune regulation
 Myeloid A2BR knockout
 Pregnancy
K10plus-PPN:1921630884
Verknüpfungen:→ Zeitschrift

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