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| Verfasst von: | Dietz-Ziegler, Stefanie [VerfasserIn]  |
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| | Hebel, Janine [VerfasserIn] |
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| | Rühle, Jessica [VerfasserIn] |
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| | Huff, Alisha [VerfasserIn] |
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| | Eltzschig, Holger K. [VerfasserIn] |
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| | Lajqi, Trim [VerfasserIn] |
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| | Poets, Christian F. [VerfasserIn] |
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| | Gille, Christian [VerfasserIn] |
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| | Köstlin-Gille, Natascha [VerfasserIn] |
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| Titel: | Impact of the adenosine receptor A2BR expressed on myeloid cells on immune regulation during pregnancy |
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| Verf.angabe: | Stefanie Dietz, Janine Hebel, Jessica Rühle, Alisha Huff, Holger K. Eltzschig, Trim Lajqi, Christian F. Poets, Christian Gille and Natascha Köstlin-Gille |
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| E-Jahr: | 2024 |
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| Jahr: | December 2024 |
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| Umfang: | 14 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Veröffentlicht: 25 October 2024 ; Gesehen am 07.04.2025 |
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| Titel Quelle: | Enthalten in: European journal of immunology |
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| Ort Quelle: | Weinheim : Wiley-VCH, 1971 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 54(2024), 12 vom: Dez., Artikel-ID 2451149, Seite 1-14 |
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| ISSN Quelle: | 1521-4141 |
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| Abstract: | During pregnancy, the maternal immune system must carefully balance protection against pathogens with tolerance toward the semiallogeneic fetus. Dysfunctions of the immune system can lead to severe complications such as preeclampsia, fetal growth restriction, or pregnancy loss. Adenosine plays a role in physiological processes and plasma-level increase during pregnancy. The adenosine receptor A2B (A2BR), which is expressed on both, immune and nonimmune cells, is activated by high adenosine concentrations, achieved during pregnancy. We investigated the impact of A2BR expressed on myeloid cells on immune regulation during pregnancy using a mouse model with myeloid deficiency for A2BR. We demonstrate systemic changes in myeloid and lymphoid cell populations during pregnancy in A2BR-KO (Adora2B923f/f-LysMCre) mice with increased monocytes, neutrophils, and T cells but decreased B cells as well as altered T-cell subpopulations with decreased Th1 cells and Tregs and increased Th17 cells. Lack of A2BR on myeloid cells caused an increased systemic expression of IL-6 but decreased systemic accumulation and function of MDSC and reduced numbers of uterine natural killer cells. The pregnancy outcome was only marginally affected. Our results demonstrate that A2BR on myeloid cells plays a role in immune regulation during pregnancy, but the clinical impact on pregnancy remains unclear. |
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| DOI: | doi:10.1002/eji.202451149 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/eji.202451149 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202451149 |
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| | DOI: https://doi.org/10.1002/eji.202451149 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adenosine receptor |
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| | Immune regulation |
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| | Myeloid A2BR knockout |
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| | Pregnancy |
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| K10plus-PPN: | 1921630884 |
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| Verknüpfungen: | → Zeitschrift |
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Impact of the adenosine receptor A2BR expressed on myeloid cells on immune regulation during pregnancy / Dietz-Ziegler, Stefanie [VerfasserIn]; December 2024 (Online-Ressource)
