| |  Online-Ressource |
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| Verfasst von: | Angelova, Assia L. [VerfasserIn]  |
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| | Barf, Milena [VerfasserIn] |
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| | Just, Alexandra [VerfasserIn] |
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| | Leuchs, Barbara [VerfasserIn] |
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| | Rommelaere, Jean [VerfasserIn] |
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| | Ungerechts, Guy [VerfasserIn] |
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| Titel: | H-1 parvovirus-induced oncolysis and tumor microenvironment immune modulation in a novel heterotypic spheroid model of cutaneous T-cell lymphoma |
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| Verf.angabe: | Assia Angelova, Milena Barf, Alexandra Just, Barbara Leuchs, Jean Rommelaere and Guy Ungerechts |
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| E-Jahr: | 2024 |
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| Jahr: | August-1 2024 |
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| Umfang: | 21 S. |
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| Fussnoten: | Veröffentlicht: 30. Juli 2024 ; Gesehen am 07.04.2025 |
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| Weitere Titel: | Titel des special issue: Oncolytic viruses as an emerging aspect of immune oncology |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 16(2024), 15, special issue, Artikel-ID 2711, Seite 1-21 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | The rat protoparvovirus H-1 (H-1PV) is an oncolytic virus known for its anticancer properties in laboratory models of various human tumors, including non-Hodgkin lymphomas (NHL) of B-cell origin. However, H-1PV therapeutic potential against hematological malignancies of T-cell origin remains underexplored. The aim of the present study was to conduct a pilot preclinical investigation of H-1PV-mediated oncolytic effects in cutaneous T-cell lymphoma (CTCL), a type of NHL that is urgently calling for innovative therapies. We demonstrated H-1PV productive infection and induction of oncolysis in both classically grown CTCL suspension cultures and in a novel, in vivo-relevant, heterotypic spheroid model, but not in healthy donor controls, including peripheral blood mononuclear cells (PBMCs). H-1PV-mediated oncolysis of CTCL cells was not prevented by Bcl-2 overexpression and was accompanied by increased extracellular ATP release. In CTCL spheroid co-cultures with PBMCs, increased spheroid infiltration with immune cells was detected upon co-culture treatment with the virus. In conclusion, our preclinical data show that H-1PV may hold significant potential as an ingenious viroimmunotherapeutic drug candidate against CTCL. |
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| DOI: | doi:10.3390/cancers16152711 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/cancers16152711 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2072-6694/16/15/2711 |
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| | DOI: https://doi.org/10.3390/cancers16152711 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cutaneous T-cell lymphoma (CTCL) |
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| | heterotypic CTCL spheroid |
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| | oncolytic H-1 parvovirus |
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| | virotherapy |
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| K10plus-PPN: | 1921666919 |
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| Verknüpfungen: | → Zeitschrift |
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H-1 parvovirus-induced oncolysis and tumor microenvironment immune modulation in a novel heterotypic spheroid model of cutaneous T-cell lymphoma / Angelova, Assia L. [VerfasserIn]; August-1 2024 (Online-Ressource)
