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| Verfasst von: | Formozov, Andrey [VerfasserIn]  |
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| | Dieter, Alexander [VerfasserIn] |
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| | Lamarre, Joseph [VerfasserIn] |
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| | Laurence, Audrey [VerfasserIn] |
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| | Boudoux, Caroline [VerfasserIn] |
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| | Wiegert, Simon [VerfasserIn] |
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| | Beaudette, Kathy [VerfasserIn] |
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| Titel: | Fused-fiber-photometry based on a low-autofluorescence wideband multimode circulator |
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| Verf.angabe: | Andrey Formozov, Alexander Dieter, Joseph Lamarre, Audrey Laurence, Caroline Boudoux, J. Simon Wiegert, and Kathy Beaudette |
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| E-Jahr: | 2024 |
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| Jahr: | 2 Dec 2024 |
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| Umfang: | 12 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 26. November 2024 ; Gesehen am 08.04.2025 |
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| Titel Quelle: | Enthalten in: Optics express |
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| Ort Quelle: | Washington, DC : Optica, 1997 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 32(2024), 25 vom: Dez., Seite 44958-44969 |
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| ISSN Quelle: | 1094-4087 |
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| Abstract: | Analysis of fluorescent signals in biological samples is widely used in the fields of life science and medicine and can be achieved through conceptually distinct approaches. Here, we report the use of a wideband multimode circulator (WMC), a three-port optical fused-fiber device with an asymmetrical structure specifically designed to ensure efficient light transmission in both illumination and collection paths. It features a flat spectral response and is ideally suited for simultaneous excitation and detection of fluorescence in biological tissue. The WMC used in this work was further improved by minimizing its inherent background autofluorescence. Using the WMC, we demonstrate improved fluorescence detection against already existing fiber-based approaches. Finally, we utilize the WMC to establish fiber photometry recordings in vivo to infer neuronal activity in a small neuromodulatory nucleus in the brainstem of an awake mouse. |
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| DOI: | doi:10.1364/OE.537607 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1364/OE.537607 |
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| | kostenfrei: Volltext: https://opg.optica.org/oe/abstract.cfm?uri=oe-32-25-44958 |
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| | DOI: https://doi.org/10.1364/OE.537607 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Diffuse reflectance |
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| | Fiber bundles |
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| | Fiber optic couplers |
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| | Multimode fibers |
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| | Optical properties |
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| | Tissue optics |
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| K10plus-PPN: | 1921786973 |
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| Verknüpfungen: | → Zeitschrift |
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Fused-fiber-photometry based on a low-autofluorescence wideband multimode circulator / Formozov, Andrey [VerfasserIn]; 2 Dec 2024 (Online-Ressource)
