Impact of heavy metals on hormonal and immunological factors in women with repeated miscarriages

• Verfasst von: Gerhard, Ingrid [VerfasserIn]
• Verfasst von: Waibel, Sylke [VerfasserIn]
• Verfasst von: Daniel, Volker [VerfasserIn]
• Verfasst von: Runnebaum, Benno [VerfasserIn]
• Titel: Impact of heavy metals on hormonal and immunological factors in women with repeated miscarriages
• Verf.angabe: I Gerhard, S Waibel, V Daniel, B Runnebaum
• E-Jahr: 1998
• Jahr: 01 May 1998
• Umfang: 9 S.
• Fussnoten: Gesehen am 09.04.2025
• Titel Quelle: Enthalten in: Human reproduction update
• Ort Quelle: Oxford : Oxford Univ. Press, 1995
• Jahr Quelle: 1998
• Band/Heft Quelle: 4(1998), 3, Seite 301-309
• ISSN Quelle: 1460-2369
• DOI: doi:10.1093/humupd/4.3.301
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1922010103

Abstract

In 111 women with repeated miscarriages, the urinary excretion of heavy metals was determined in a challenge test with the chelating agent 2,3-dimercaptopropane-l-sulphonic acid in addition to hormonal, chromosomal, immunological and uterine investigations. The heavy metal excretion was correlated to different immunological (natural killer cells, T cell subpopulations) and hormonal (progesterone, oestradiol, prolactin, thyroid stimulating hormone) parameters. We conclude that heavy metals seem to have a negative impact on ovarian as well as on pituitary function. The heavy metal-induced immunological changes may interfere with the physiological adaptation of the immune system to the state of pregnancy with the result of a miscarriage. The observed heavy metal-induced hormonal and immunological changes may be important factors in the pathogenesis of repeated miscarriages.Key words:DMPS testing/heavy metals/immunology/ infertility/repeated miscarriages