| |  Online-Ressource |
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| Verfasst von: | Kremer, Thomas [VerfasserIn]  |
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| | Chen, Junfang [VerfasserIn] |
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| | Buhl, Anais [VerfasserIn] |
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| | Berhe, Oksana [VerfasserIn] |
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| | Bilek, Edda [VerfasserIn] |
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| | Geiger-Primo, Lena S. [VerfasserIn] |
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| | Ma, Ren [VerfasserIn] |
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| | Mößnang, Carolin Ulrike [VerfasserIn] |
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| | Reichert, Markus [VerfasserIn] |
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| | Reinhard, Iris [VerfasserIn] |
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| | Schwarz, Kristina [VerfasserIn] |
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| | Schweiger, Janina [VerfasserIn] |
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| | Streit, Fabian [VerfasserIn] |
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| | Witt, Stephanie [VerfasserIn] |
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| | Zang, Zhenxiang [VerfasserIn] |
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| | Zhang, Xiaolong [VerfasserIn] |
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| | Nöthen, Markus Maria [VerfasserIn] |
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| | Rietschel, Marcella [VerfasserIn] |
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| | Ebner-Priemer, Ulrich [VerfasserIn] |
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| | Schwarz, Emanuel [VerfasserIn] |
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| | Meyer-Lindenberg, Andreas [VerfasserIn] |
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| | Braun, Urs [VerfasserIn] |
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| | Tost, Heike [VerfasserIn] |
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| Titel: | Multimodal associations of FKBP5 methylation with emotion-regulatory brain circuits |
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| Verf.angabe: | Thomas L. Kremer, Junfang Chen, Anais Buhl, Oksana Berhe, Edda Bilek, Lena S. Geiger, Ren Ma, Carolin Moessnang, Markus Reichert, Iris Reinhard, Kristina Schwarz, Janina I. Schweiger, Fabian Streit, Stephanie H. Witt, Zhenxiang Zang, Xiaolong Zhang, Markus M. Nöthen, Marcella Rietschel, Ulrich W. Ebner-Priemer, Emanuel Schwarz, Andreas Meyer-Lindenberg, Urs Braun, and Heike Tost |
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| E-Jahr: | 2024 |
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| Jahr: | 1 December 2024 |
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| Umfang: | 10 S. |
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| Fussnoten: | Online verfügbar: 7. März 2024, Artikelversion: 28. Oktober 2024 ; Gesehen am 14.04.2025 |
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| Titel Quelle: | Enthalten in: Biological psychiatry |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1985 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 96(2024), 11 vom: Dez., Seite 858-867 |
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| ISSN Quelle: | 1873-2402 |
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| Abstract: | Background - Understanding the biological processes that underlie individual differences in emotion regulation and stress responsivity is a key challenge for translational neuroscience. The gene FKBP5 is a core regulator in molecular stress signaling that is implicated in the development of psychiatric disorders. However, it remains unclear how FKBP5 DNA methylation in peripheral blood is related to individual differences in measures of neural structure and function and their relevance to daily-life stress responsivity. - Methods - Here, we characterized multimodal correlates of FKBP5 DNA methylation by combining epigenetic data with neuroimaging and ambulatory assessment in a sample of 395 healthy individuals. - Results - First, we showed that FKBP5 demethylation as a psychiatric risk factor was related to an anxiety-associated reduction of gray matter volume in the ventromedial prefrontal cortex, a brain area that is involved in emotion regulation and mental health risk and resilience. This effect of epigenetic upregulation of FKBP5 on neuronal structure is more pronounced where FKBP5 is epigenetically downregulated at baseline. Leveraging 208 functional magnetic resonance imaging scans during a well-established emotion-processing task, we found that FKBP5 DNA methylation in peripheral blood was associated with functional differences in prefrontal-limbic circuits that modulate affective responsivity to daily stressors, which we measured using ecological momentary assessment in daily life. - Conclusions - Overall, we demonstrated how FKBP5 contributes to interindividual differences in neural and real-life affect regulation via structural and functional changes in prefrontal-limbic brain circuits. |
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| DOI: | doi:10.1016/j.biopsych.2024.03.003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.biopsych.2024.03.003 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0006322324011417 |
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| | DOI: https://doi.org/10.1016/j.biopsych.2024.03.003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Ambulatory assessment |
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| | Epigenetics |
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| | Prefrontal cortex |
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| | Stress |
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| K10plus-PPN: | 1922825832 |
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| Verknüpfungen: | → Zeitschrift |
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Multimodal associations of FKBP5 methylation with emotion-regulatory brain circuits / Kremer, Thomas [VerfasserIn]; 1 December 2024 (Online-Ressource)
