| Online-Ressource |
Verfasst von: | Sparano, Colin [VerfasserIn]  |
| Solís-Sayago, Darío [VerfasserIn]  |
| Zangger, Nathan Sébastien [VerfasserIn]  |
| Rindlisbacher, Lukas [VerfasserIn]  |
| Van Hove, Hannah [VerfasserIn]  |
| Vermeer, Marijne [VerfasserIn]  |
| Westermann, Frederike [VerfasserIn]  |
| Mussak, Caroline [VerfasserIn]  |
| Rallo, Elisa [VerfasserIn]  |
| Dergun, Stanislav [VerfasserIn]  |
| Litscher, Gioana [VerfasserIn]  |
| Xu, Yishu [VerfasserIn]  |
| Bijnen, Mitchell [VerfasserIn]  |
| Friedrich, Christin [VerfasserIn]  |
| Greter, Melanie [VerfasserIn]  |
| Juranić Lisnić, Vanda [VerfasserIn]  |
| Becher, Burkhard [VerfasserIn]  |
| Gasteiger, Georg [VerfasserIn]  |
| Oxenius, Annette [VerfasserIn]  |
| Tugues, Sònia [VerfasserIn]  |
Titel: | Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells |
Verf.angabe: | Colin Sparano, Darío Solís-Sayago, Nathan Sébastien Zangger, Lukas Rindlisbacher, Hannah Van Hove, Marijne Vermeer, Frederike Westermann, Caroline Mussak, Elisa Rallo, Stanislav Dergun, Gioana Litscher, Yishu Xu, Mitchell Bijnen, Christin Friedrich, Melanie Greter, Vanda Juranić Lisnić, Burkhard Becher, Georg Gasteiger, Annette Oxenius, and Sonia Tugues |
E-Jahr: | 2024 |
Jahr: | December 18 2024 |
Umfang: | 24 S. |
Illustrationen: | Illustrationen, Diagramme |
Fussnoten: | Gesehen am 22.04.2025 |
Weitere Titel: | Titel des übergeordneten Heftes: Tissue microenvironment and immune memory |
Titel Quelle: | Enthalten in: Journal of experimental medicine |
Ort Quelle: | New York, NY : Rockefeller Univ. Press, 1896 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 222(2024), 3, Artikel-ID e20240930, Seite 1-17, S1-7 |
ISSN Quelle: | 1540-9538 |
Abstract: | Group 1 innate lymphoid cells (ILCs) encompass NK cells and ILC1s, which have non-redundant roles in host protection against pathogens and cancer. Despite their circulating nature, NK cells can establish residency in selected tissues during ontogeny, forming a distinct functional subset. The mechanisms that initiate, maintain, and regulate the conversion of NK cells into tissue-resident NK (trNK) cells are currently not well understood. Here, we identify autocrine transforming growth factor-β (TGF-β) as a cell-autonomous driver for NK cell tissue residency across multiple glandular tissues during development. Cell-intrinsic production of TGF-β was continuously required for the maintenance of trNK cells and synergized with Hobit to enhance cytotoxic function. Whereas autocrine TGF-β was redundant in tumors, our study revealed that NK cell-derived TGF-β allowed the expansion of cytotoxic trNK cells during local infection with murine cytomegalovirus (MCMV) and contributed to viral control in the salivary gland. Collectively, our findings reveal tissue-specific regulation of trNK cell differentiation and function by autocrine TGF-β1, which is relevant for antiviral immunity. |
DOI: | doi:10.1084/jem.20240930 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1084/jem.20240930 |
| DOI: https://doi.org/10.1084/jem.20240930 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 192337947X |
Verknüpfungen: | → Zeitschrift |
Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells / Sparano, Colin [VerfasserIn]; December 18 2024 (Online-Ressource)