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| Verfasst von: | Kayvanpour, Elham [VerfasserIn]  |
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| | Sedaghat-Hamedani, Farbod [VerfasserIn] |
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| | Li, Daniel Tian [VerfasserIn] |
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| | Miersch, Tobias [VerfasserIn] |
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| | Weis, Tanja [VerfasserIn] |
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| | Hoefer, Imo [VerfasserIn] |
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| | Frey, Norbert [VerfasserIn] |
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| | Meder, Benjamin [VerfasserIn] |
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| Titel: | Prognostic value of circulating fibrosis biomarkers in dilated cardiomyopathy (DCM) |
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| Titelzusatz: | insights into clinical outcomes |
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| Verf.angabe: | Elham Kayvanpour, Farbod Sedaghat-Hamedani, Daniel Tian Li, Tobias Miersch, Tanja Weis, Imo Hoefer, Norbert Frey and Benjamin Meder |
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| E-Jahr: | 2024 |
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| Jahr: | 9 September 2024 |
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| Umfang: | 12 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 22.04.2025 |
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| Titel Quelle: | Enthalten in: Biomolecules |
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| Ort Quelle: | Basel : MDPI, 2011 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 14(2024), 9, Artikel-ID 1137, Seite 1-12 |
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| ISSN Quelle: | 2218-273X |
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| Abstract: | Background: Dilated cardiomyopathy (DCM) involves myocardial remodeling, characterized by significant fibrosis and extracellular matrix expansion. These changes impair heart function, increasing the risk of heart failure and sudden cardiac death. This study investigates the prognostic value of circulating fibrosis biomarkers as a less invasive method in DCM patients. Methods: Plasma samples from 185 patients with confirmed DCM were analyzed to measure 13 circulating biomarkers using Luminex bead-based multiplex assays and ELISA. The prognostic value of these biomarkers was evaluated concerning heart failure-associated events and all-cause mortality. Results: Elevated MMP-2 levels (>1519.3 ng/mL) were linked to older age, higher diabetes prevalence, lower HDL, increased NT-proBNP and hs-TnT levels, and severe systolic dysfunction. High TIMP-1 levels (>124.9 ng/mL) correlated with elevated NT-proBNP, more atrial fibrillation, reduced exercise capacity, and larger right ventricles. Increased GDF-15 levels (>1213.9 ng/mL) were associated with older age, systemic inflammation, renal impairment, and poor exercise performance. Elevated OPN levels (>81.7 ng/mL) were linked to higher serum creatinine and NT-proBNP levels. Over a median follow-up of 32.4 months, higher levels of these biomarkers predicted worse outcomes, including increased risks of heart failure-related events and mortality. Conclusions: Circulating fibrosis biomarkers, particularly MMP-2, TIMP-1, GDF-15, and OPN, are valuable prognostic tools in DCM. They reflect the severity of myocardial remodeling and systemic disease burden, aiding in risk stratification and therapeutic intervention. Integrating these biomarkers into clinical practice could improve DCM management and patient prognosis. |
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| DOI: | doi:10.3390/biom14091137 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/biom14091137 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2218-273X/14/9/1137 |
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| | DOI: https://doi.org/10.3390/biom14091137 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | biomarkers |
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| | cardiac fibrosis |
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| | dilated cardiomyopathy |
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| | GDF-15 |
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| | MMP-2 |
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| | OPN |
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| | TIMP-1 |
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| K10plus-PPN: | 192340914X |
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| Verknüpfungen: | → Zeitschrift |
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Prognostic value of circulating fibrosis biomarkers in dilated cardiomyopathy (DCM) / Kayvanpour, Elham [VerfasserIn]; 9 September 2024 (Online-Ressource)
