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| Verfasst von: | Shiraishi, Ryo [VerfasserIn]  |
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| | Cancila, Gabriele [VerfasserIn] |
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| | Kumegawa, Kohei [VerfasserIn] |
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| | Torrejon, Jacob [VerfasserIn] |
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| | Basili, Irene [VerfasserIn] |
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| | Bernardi, Flavia [VerfasserIn] |
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| | Silva, Patricia Benites Gonçalves da [VerfasserIn] |
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| | Wang, Wanchen [VerfasserIn] |
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| | Chapman, Owen [VerfasserIn] |
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| | Yang, Liying [VerfasserIn] |
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| | Jami, Maki [VerfasserIn] |
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| | Nishitani, Kayo [VerfasserIn] |
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| | Arai, Yukimi [VerfasserIn] |
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| | Xiao, Zhize [VerfasserIn] |
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| | Yu, Hua [VerfasserIn] |
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| | Lo Re, Valentina [VerfasserIn] |
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| | Marsaud, Véronique [VerfasserIn] |
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| | Talbot, Julie [VerfasserIn] |
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| | Lombard, Bérangère [VerfasserIn] |
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| | Loew, Damarys [VerfasserIn] |
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| | Jingu, Maho [VerfasserIn] |
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| | Okonechnikov, Konstantin [VerfasserIn] |
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| | Sone, Masaki [VerfasserIn] |
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| | Motohashi, Norio [VerfasserIn] |
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| | Aoki, Yoshitsugu [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Chavez, Lukas [VerfasserIn] |
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| | Hoshino, Mikio [VerfasserIn] |
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| | Maruyama, Reo [VerfasserIn] |
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| | Ayrault, Olivier [VerfasserIn] |
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| | Kawauchi, Daisuke [VerfasserIn] |
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| Titel: | Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression |
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| Verf.angabe: | Ryo Shiraishi, Gabriele Cancila, Kohei Kumegawa, Jacob Torrejon, Irene Basili, Flavia Bernardi, Patricia Benites Goncalves da Silva, Wanchen Wang, Owen Chapman, Liying Yang, Maki Jami, Kayo Nishitani, Yukimi Arai, Zhize Xiao, Hua Yu, Valentina Lo Re, Véronique Marsaud, Julie Talbot, Bérangère Lombard, Damarys Loew, Maho Jingu, Konstantin Okonechnikov, Masaki Sone, Norio Motohashi, Yoshitsugu Aoki, Stefan M. Pfister, Lukas Chavez, Mikio Hoshino, Reo Maruyama, Olivier Ayrault, and Daisuke Kawauchi |
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| E-Jahr: | 2024 |
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| Jahr: | 9 September 2024 |
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| Umfang: | 30 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 03. Juni 2024 ; Gesehen am 24.04.2025 |
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| Titel Quelle: | Enthalten in: Developmental cell |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 2001 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 59(2024), 17, Seite 2302-2319, e1-12 |
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| ISSN Quelle: | 1878-1551 |
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| Abstract: | Normal cells coordinate proliferation and differentiation by precise tuning of gene expression based on the dynamic shifts of the epigenome throughout the developmental timeline. Although non-mutational epigenetic reprogramming is an emerging hallmark of cancer, the epigenomic shifts that occur during the transition from normal to malignant cells remain elusive. Here, we capture the epigenomic changes that occur during tumorigenesis in a prototypic embryonal brain tumor, medulloblastoma. By comparing the epigenomes of the different stages of transforming cells in mice, we identify nuclear factor I family of transcription factors, known to be cell fate determinants in development, as oncogenic regulators in the epigenomes of precancerous and cancerous cells. Furthermore, genetic and pharmacological inhibition of NFIB validated a crucial role of this transcription factor by disrupting the cancer epigenome in medulloblastoma. Thus, this study exemplifies how epigenomic changes contribute to tumorigenesis via non-mutational mechanisms involving developmental transcription factors. |
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| DOI: | doi:10.1016/j.devcel.2024.05.013 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.devcel.2024.05.013 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1534580724003307 |
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| | DOI: https://doi.org/10.1016/j.devcel.2024.05.013 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | brain tumor |
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| | cerebellar granule cell |
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| | cerebellum |
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| | epigenome |
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| | medulloblastoma |
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| | mouse model |
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| | nuclear factor I |
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| K10plus-PPN: | 192361150X |
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| Verknüpfungen: | → Zeitschrift |
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Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression / Shiraishi, Ryo [VerfasserIn]; 9 September 2024 (Online-Ressource)
