| |  Online-Ressource |
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| Verfasst von: | Begovic, Merima [VerfasserIn]  |
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| | Schneider, Luca [VerfasserIn] |
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| | Zhou, Xiao-Bo [VerfasserIn] |
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| | Hamdani, Nazha [VerfasserIn] |
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| | Akın, Ibrahim [VerfasserIn] |
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| | El-Battrawy, Ibrahim [VerfasserIn] |
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| Titel: | The role of human-induced pluripotent stem cells in studying cardiac channelopathies |
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| Verf.angabe: | Merima Begovic, Luca Schneider, Xiaobo Zhou, Nazha Hamdani, Ibrahim Akin and Ibrahim El-Battrawy |
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| E-Jahr: | 2024 |
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| Jahr: | 8 November 2024 |
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| Umfang: | 25 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 30.04.2025 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 25(2024), 22, Artikel-ID 12034, Seite 1-25 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Cardiac channelopathies are inherited diseases that increase the risk of sudden cardiac death. While different genes have been associated with inherited channelopathies, there are still subtypes, e.g., catecholaminergic polymorphic ventricular tachycardia and Brugada syndrome, where the genetic cause remains unknown. Various models, including animal models, heterologous expression systems, and the human-induced pluripotent stem-cell-derived cardiomyocytes (hiPSCs-CMs) model, have been used to study the pathophysiological mechanisms of channelopathies. Recently, researchers have focused on using hiPSCs-CMs to understand the genotype-phenotype correlation and screen drugs. By combining innovative techniques such as Clustered Regularly Interspaced Short Palindromic Repeats/Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9 (CRISPR/Cas9)-mediated genome editing, and three-dimensional (3D) engineered heart tissues, we can gain new insights into the pathophysiological mechanisms of channelopathies. This approach holds promise for improving personalized drug treatment. This review highlights the role of hiPSCs-CMs in understanding the pathomechanism of Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia and how these models can be utilized for drug screening. |
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| DOI: | doi:10.3390/ijms252212034 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/ijms252212034 |
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| | kostenfrei: Volltext: https://www.mdpi.com/1422-0067/25/22/12034 |
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| | DOI: https://doi.org/10.3390/ijms252212034 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Brugada syndrome |
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| | catecholaminergic polymorphic ventricular tachycardia |
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| | sudden cardiac death |
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| K10plus-PPN: | 1924013290 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ role of human-induced pluripotent stem cells in studying cardiac channelopathies / Begovic, Merima [VerfasserIn]; 8 November 2024 (Online-Ressource)
