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| Verfasst von: | Şener Gürsoy, Özge Çiçek [VerfasserIn]  |
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| | Melchers, Susanne [VerfasserIn] |
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| | Tengler, Luisa [VerfasserIn] |
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| | Beltzig, Paul L. [VerfasserIn] |
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| | Albrecht, Jana Dorothea [VerfasserIn] |
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| | Tümen, Deniz [VerfasserIn] |
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| | Gülow, Karsten [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| | Goerdt, Sergij [VerfasserIn] |
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| | Hein, Tobias [VerfasserIn] |
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| | Nicolay, Jan Peter [VerfasserIn] |
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| Titel: | Dimethyl fumarate and extracorporeal photopheresis combination-therapy synergize in inducing specific cell death and long-term remission in cutaneous T cell lymphoma |
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| Titelzusatz: | lymphoma |
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| Verf.angabe: | Özge Ç Şener, Susanne Melchers, Luisa Tengler, Paul L. Beltzig, Jana D. Albrecht, Deniz Tümen, Karsten Gülow, Jochen S. Utikal, Sergij Goerdt, Tobias Hein and Jan P. Nicolay |
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| E-Jahr: | 2025 |
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| Jahr: | February 2025 |
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| Umfang: | 13 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 23. November 2024 ; Gesehen am 06.05.2025 |
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| Titel Quelle: | Enthalten in: Leukemia |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 39(2025), 2 vom: Feb., Seite 438-450 |
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| ISSN Quelle: | 1476-5551 |
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| Abstract: | Primary cutaneous T cell lymphomas (CTCL) are characterized by high relapse rates to initially highly effective therapies. Combination therapies have proven beneficial, particularly if they incorporate extracorporeal photopheresis (ECP). The NF-κB inhibitor dimethyl fumarate (DMF) has proven a new, effective drug in CTCL in a clinical phase II study. In vitro experiments with patient-derived SS cells and the CTCL cell lines HH, HuT 78, and SeAx revealed a synergistic effect of DMF and ECP on cell death induction in CTCL cells. Furthermore, an additional increase in the capacity to inhibit NF-κB in CTCL was detected for the combination treatment compared to DMF monotherapy. The same synergistic effects could be measured for ROS production via decreased Thioredoxin reductase activity and glutathione levels. Consequently, a cell death inhibitor screen indicated that the DMF/ECP combination treatment induces a variety of cell death mechanisms in CTCL. As a first step into clinical translation, 4 patients were already treated with the DMF/ECP combination therapy with an overall response rate of 100% and a time to next treatment in skin and blood of up to 57 months. Therefore, our study introduces the combination treatment of DMF and ECP as a highly effective and long-lasting CTCL therapy. |
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| DOI: | doi:10.1038/s41375-024-02479-1 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41375-024-02479-1 |
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| | kostenfrei: Volltext: http://www.nature.com/articles/s41375-024-02479-1 |
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| | DOI: https://doi.org/10.1038/s41375-024-02479-1 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | T-cell lymphoma |
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| | Translational research |
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| K10plus-PPN: | 1924740931 |
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| Verknüpfungen: | → Zeitschrift |
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Dimethyl fumarate and extracorporeal photopheresis combination-therapy synergize in inducing specific cell death and long-term remission in cutaneous T cell lymphoma / Şener Gürsoy, Özge Çiçek [VerfasserIn]; February 2025 (Online-Ressource)
