Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance

• Verfasst von: Ambroziak, Wojciech [VerfasserIn]
• Verfasst von: Nencini, Sara [VerfasserIn]
• Verfasst von: Pohle, Jörg [VerfasserIn]
• Verfasst von: Žuža, Kristina [VerfasserIn]
• Verfasst von: Pino, Gabriela [VerfasserIn]
• Verfasst von: Lundh, Sofia [VerfasserIn]
• Verfasst von: Araujo Sousa, Carolina [VerfasserIn]
• Verfasst von: Götz, Larissa [VerfasserIn]
• Verfasst von: Schrenk-Siemens, Katrin [VerfasserIn]
• Verfasst von: Manoj, Gokul [VerfasserIn]
• Verfasst von: Gutierrez-Herrera, Mildred A. [VerfasserIn]
• Verfasst von: Acuna Goycolea, Claudio [VerfasserIn]
• Verfasst von: Siemens, Jan [VerfasserIn]
• Titel: Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance
• Verf.angabe: Wojciech Ambroziak, Sara Nencini, Jörg Pohle, Kristina Zuza, Gabriela Pino, Sofia Lundh, Carolina Araujo-Sousa, Larissa I.L. Goetz, Katrin Schrenk-Siemens, Gokul Manoj, Mildred A. Herrera, Claudio Acuna & Jan Siemens
• E-Jahr: 2025
• Jahr: February 2025
• Umfang: 45 S.
• Illustrationen: Illustrationen
• Fussnoten: Online veröffentlicht: 09. Dezember 2024 ; Gesehen am 06.05.2025
• Titel Quelle: Enthalten in: Nature neuroscience
• Ort Quelle: New York, NY : Nature America, 1998
• Jahr Quelle: 2025
• Band/Heft Quelle: 28(2025), 2 vom: Feb., Seite 346-360,[1-30]
• ISSN Quelle: 1546-1726
• DOI: doi:10.1038/s41593-024-01830-0
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Neuroscience
• Sach-SW: Physiology
• K10plus-PPN: 1924757273

Abstract

Heat acclimation is an adaptive process that improves physiological performance and supports survival in the face of increasing environmental temperatures, but the underlying mechanisms are not well understood. Here we identified a discrete group of neurons in the mouse hypothalamic preoptic area (POA) that rheostatically increase their activity over the course of heat acclimation, a property required for mice to become heat tolerant. In non-acclimated mice, peripheral thermoafferent pathways via the parabrachial nucleus activate POA neurons and mediate acute heat-defense mechanisms. However, long-term heat exposure promotes the POA neurons to gain intrinsically warm-sensitive activity, independent of thermoafferent parabrachial input. This newly gained cell-autonomous warm sensitivity is required to recruit peripheral heat tolerance mechanisms in acclimated animals. This pacemaker-like, warm-sensitive activity is driven by a combination of increased sodium leak current and enhanced utilization of the NaV1.3 ion channel. We propose that this salient neuronal plasticity mechanism adaptively drives acclimation to promote heat tolerance.