Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Kronenwett, Ralf [VerfasserIn]  |
| Haas, Rainer [VerfasserIn]  |
Titel: | Antisense strategies for the treatment of hematological malignancies and solid tumors |
Verf.angabe: | R. Kronenwett, R. Haas |
E-Jahr: | 1998 |
Jahr: | August 1998 |
Umfang: | 12 S. |
Fussnoten: | Gesehen am 08.05.2025 |
Titel Quelle: | Enthalten in: Annals of hematology |
Ort Quelle: | Berlin : Springer, 1991 |
Jahr Quelle: | 1998 |
Band/Heft Quelle: | 77(1998), 1, Seite 1-12 |
ISSN Quelle: | 1432-0584 |
Abstract: | If malignant growth is considered the result of abnormal gene expression, it is reasonable to use antisense nucleic acids for the treatment of malignant diseases. Antisense oligonucleotides can specifically down-regulate gene expression, and a number of first-generation antisense compounds have entered human clinical trials. In this review, some aspects relevant for the development of antisense-based drugs, such as the selection of appropriate target sequences, cellular delivery, and design of a clinical study, are described, using bcr-abl-oncogene-directed antisense oligonucleotides as an example. In addition, potential target genes for antisense inhibition in hematology and oncology, including oncogenes and adhesion molecules, are summarized. Down-regulation of such adhesion molecules as members of the immunoglobulin superfamily and integrins may provide new modalities for mobilization of CD34+ hematopoietic stem cells into the peripheral blood. The review closes with an overview of ongoing clinical trials in the treatment of malignant diseases by antisense oligonucleotides. |
DOI: | doi:10.1007/s002770050404 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s002770050404 |
| DOI: https://doi.org/10.1007/s002770050404 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | >Keywords Antisense nucleic acids |
| Cellular uptake |
| Clinical studies |
| Molecular therapy |
| Target genes |
K10plus-PPN: | 192508048X |
Verknüpfungen: | → Zeitschrift |
Antisense strategies for the treatment of hematological malignancies and solid tumors / Kronenwett, Ralf [VerfasserIn]; August 1998 (Online-Ressource)
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