Auto-contouring of cardiac substructures for stereotactic arrhythmia radioablation (STAR)

• Verfasst von: Van der Pol, Luuk [VerfasserIn]
• Verfasst von: Blanck, Oliver [VerfasserIn]
• Verfasst von: Grehn, Melanie [VerfasserIn]
• Verfasst von: Blazek, Tomáš [VerfasserIn]
• Verfasst von: Knybel, Lukáš [VerfasserIn]
• Verfasst von: Balgobind, Brian V. [VerfasserIn]
• Verfasst von: Verhoeff, Joost J. C. [VerfasserIn]
• Verfasst von: Miszczyk, Marcin [VerfasserIn]
• Verfasst von: Blamek, Slawomir [VerfasserIn]
• Verfasst von: Reichl, Sabrina [VerfasserIn]
• Verfasst von: Andratschke, Nicolaus [VerfasserIn]
• Verfasst von: Mehrhof, Felix [VerfasserIn]
• Verfasst von: Boda-Heggemann, Judit [VerfasserIn]
• Verfasst von: Tomasik, Bartłomiej [VerfasserIn]
• Verfasst von: Mandija, Stefano [VerfasserIn]
• Verfasst von: Fast, Martin F. [VerfasserIn]
• Titel: Auto-contouring of cardiac substructures for stereotactic arrhythmia radioablation (STAR)
• Titelzusatz: a STOPSTORM.eu consortium study
• Verf.angabe: Luuk H.G. van der Pol, Oliver Blanck, Melanie Grehn, Tomáš Blazek, Lukáš Knybel, Brian V. Balgobind, Joost J.C. Verhoeff, Marcin Miszczyk, Slawomir Blamek, Sabrina Reichl, Nicolaus Andratschke, Felix Mehrhof, Judit Boda-Heggemann, Bartłomiej Tomasik, Stefano Mandija, Martin F. Fast
• E-Jahr: 2025
• Jahr: January 2025
• Umfang: 8 S.
• Fussnoten: Online verfügbar: 1. November 2024, Artikelversion: 6. November 2024 ; Gesehen am 13.05.2025
• Titel Quelle: Enthalten in: Radiotherapy and oncology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1983
• Jahr Quelle: 2025
• Band/Heft Quelle: 202(2025) vom: Jan., Artikel-ID 110610, Seite 1-8
• ISSN Quelle: 1879-0887
• DOI: doi:10.1016/j.radonc.2024.110610
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1925462420

Abstract

Background/Purpose - High doses to healthy cardiac substructures (CS) in stereotactic arrhythmia radioablation (STAR) raise concerns regarding potential treatment-induced cardio-toxicity. However, CS contours are not routinely created, hindering the understanding of the CS dose-effect relationships. To address this issue, the alignment of CS contouring was initiated within the STOPSTORM consortium. In this study, we developed and evaluated auto-contouring models trained to delineate CS and major vessels in ventricular tachycardia (VT) patients. - Methods - Eight centres provided standard treatment planning computed tomography (CT) and/or contrast-enhanced CT datasets of 55 VT patients, each including 16 CS. Auto-contouring models were trained to contour either large structures or small structures. Dice Similarity Coefficient (DSC), 95 % Hausdorff distance (HD95) and volume ratio (VR) were used to evaluate model performance versus inter-observer variation (IOV) on seven VT patient test cases. Significant differences were tested using the Mann-Whitney U test. - Results - The performance on the four chambers and the major vessels (median DSC: 0.88; HD95: 5.8-19.4 mm; VR: 1.09) was similar to the IOV (median DSC: 0.89; HD95: 4.8-14.0 mm; VR: 1.20). For the valves, model performance (median DSC: 0.37; HD95: 11.6 mm; VR: 1.63) was similar to the IOV (median DSC: 0.41; HD95: 12.4 mm; VR: 3.42), but slightly worse for the coronary arteries (median DSC: 0.33 vs 0.42; HD95: 24.4 mm vs 16.9 mm; VR: 1.93 vs 3.30). The IOV for these small structures remains large despite using contouring guidelines. - Conclusion - CS auto-contouring models trained on VT patient data perform similarly to IOV. This allows for time-efficient evaluation of CS as possible organs-at-risk.