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Verfasst von:Chen, Ying [VerfasserIn]   i
 Schlotterer, Andrea [VerfasserIn]   i
 Lin, Jihong [VerfasserIn]   i
 Dietrich, Nadine [VerfasserIn]   i
 Fleming, Thomas [VerfasserIn]   i
 Lanzinger, Stefanie [VerfasserIn]   i
 Holl, Reinhard W. [VerfasserIn]   i
 Hammes, Hans-Peter [VerfasserIn]   i
Titel:Sex differences in the development of experimental diabetic retinopathy
Verf.angabe:Ying Chen, Andrea Schlotterer, Jihong Lin, Nadine Dietrich, Thomas Fleming, Stefanie Lanzinger, Reinhard W. Holl & Hans-Peter Hammes
E-Jahr:2024
Jahr:01 October 2024
Umfang:11 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 14.05.2025
Titel Quelle:Enthalten in: Scientific reports
Ort Quelle:[London] : Springer Nature, 2011
Jahr Quelle:2024
Band/Heft Quelle:14(2024), Artikel-ID 22812, Seite 1-11
ISSN Quelle:2045-2322
Abstract:This study aimed to characterize the role of female sex in the pathogenesis of diabetic retinopathy. In the retinae of female Ins2Akita-diabetic mice (F-IA), ovariectomized female Ins2Akita-diabetic mice (F-IA/OVX), male Ins2Akita-diabetic mice (M-IA), and female STZ-diabetic mice (F-STZ), the formation of reactive metabolites and post-translational modifications, damage to the neurovascular unit, and expression of cellular stress response genes were analyzed. Compared to the male diabetic retina, the concentrations of the glycation adduct fructosyl-lysine, the Maillard product 3-deoxyglucosone, and the reactive metabolite methylglyoxal were significantly reduced in females. In females, there was also less evidence of diabetic damage to the neurovascular unit, as shown by decreased pericyte loss and reduced microglial activation. In the male diabetic retina, the expression of several members of the crystallin gene family (Cryab, Cryaa, Crybb2, Crybb1, and Cryba4) was increased. Clinical data from type 1 diabetic females showed that premenopausal women had a significantly lower prevalence of diabetic retinopathy compared to postmenopausal women stratified for disease duration and glycemic control. These data emphasize the importance of estradiol in protecting the diabetic retina and highlight the pathogenic relevance of sex in diabetic retinopathy.
DOI:doi:10.1038/s41598-024-73279-x
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1038/s41598-024-73279-x
 kostenfrei: Volltext: https://www.nature.com/articles/s41598-024-73279-x
 DOI: https://doi.org/10.1038/s41598-024-73279-x
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Experimental models of disease
 Neurodegeneration
K10plus-PPN:1925606309
Verknüpfungen:→ Zeitschrift

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