| |  Online-Ressource |
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| Verfasst von: | Wetzel, Ethan [VerfasserIn]  |
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| | Nohman, Amin [VerfasserIn] |
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| | Hsieh, Annie L. [VerfasserIn] |
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| | Reuss, David [VerfasserIn] |
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| | Unterberg, Andreas [VerfasserIn] |
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| | Eyüpoglu, Ilker Yasin [VerfasserIn] |
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| | Hua, Lingyang [VerfasserIn] |
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| | Youssef, Gilbert [VerfasserIn] |
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| | Wen, Patrick Y. [VerfasserIn] |
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| | Cahill, Daniel P. [VerfasserIn] |
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| | Jungk, Christine [VerfasserIn] |
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| | Juratli, Tareq [VerfasserIn] |
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| | Miller, Julie J. [VerfasserIn] |
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| Titel: | A multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4 |
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| Titelzusatz: | implications for prognosis and clinical trial design |
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| Verf.angabe: | Ethan A. Wetzel, Amin I. Nohman, Annie L. Hsieh, David Reuss, Andreas W. Unterberg, Ilker Y. Eyüpoglu, Lingyang Hua, Gilbert Youssef, Patrick Y. Wen, Daniel P. Cahill, Christine Jungk, Tareq A. Juratli, Julie J. Miller |
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| E-Jahr: | 2025 |
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| Jahr: | 21 October 2024 |
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| Umfang: | 9 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 14.05.2025 |
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| Titel Quelle: | Enthalten in: Journal of neuro-oncology |
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| Ort Quelle: | Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 171(2025), 2, Seite 373-381 |
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| ISSN Quelle: | 1573-7373 |
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| Abstract: | Mutations in the Isocitrate Dehydrogenase (IDH) genes, IDH1 or IDH2, define a group of adult diffuse gliomas associated with a younger age at diagnosis and better prognosis than IDH wild-type glioblastoma. Within IDH mutant gliomas, a small fraction of astrocytic tumors present with grade 4 histologic features and poor prognosis. In molecular studies, homozygous deletion of CDKN2A/B is independently predictive of poor prognosis and short survival. As a consequence, 2021 WHO classification now also recognizes this molecular feature, CDKN2A/B deletion, as sufficient for classifying an astrocytoma as IDH-mutant, WHO Grade 4, regardless of histological grading. Here, we investigate outcomes of patients with WHO Grade 4 IDH-mutant astrocytoma both with and without CDKN2A/B deletion, to compare these groups and evaluate clinical and radiographic factors that contribute to survival. |
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| DOI: | doi:10.1007/s11060-024-04852-7 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1007/s11060-024-04852-7 |
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| | kostenfrei: Volltext: https://link.springer.com/article/10.1007/s11060-024-04852-7 |
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| | DOI: https://doi.org/10.1007/s11060-024-04852-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Astrocyte |
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| | Astrocytoma |
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| | Brain Cancer |
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| | CDKN2A/B homozygous deletion |
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| | Gene Mutation |
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| | Glioma |
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| | Huntington's disease |
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| | Idiopathic thrombocytopaenic purpura |
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| | Isocitrate dehydrogenase (IDH) |
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| | WHO grade 4 |
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| | Wilms tumour |
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| K10plus-PPN: | 1925661253 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4 / Wetzel, Ethan [VerfasserIn]; 21 October 2024 (Online-Ressource)
