Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Bayfield, Katie [VerfasserIn]   i
 Weinheimer, Oliver [VerfasserIn]   i
 Middleton, Anna [VerfasserIn]   i
 Boyton, Christie [VerfasserIn]   i
 Fitzpatrick, Rachel [VerfasserIn]   i
 Kennedy, Brendan [VerfasserIn]   i
 Blaxland, Anneliese [VerfasserIn]   i
 Jayasuriya, Geshani [VerfasserIn]   i
 Caplain, Neil [VerfasserIn]   i
 Wielpütz, Mark Oliver [VerfasserIn]   i
 Yu, Lifeng [VerfasserIn]   i
 Galban, Craig J [VerfasserIn]   i
 Robinson, Terry E [VerfasserIn]   i
 Bartholmai, Brian [VerfasserIn]   i
 Gustafsson, Per [VerfasserIn]   i
 Fitzgerald, Dominic [VerfasserIn]   i
 Selvadurai, Hiran [VerfasserIn]   i
 Robinson, Paul D [VerfasserIn]   i
Titel:Comparative sensitivity of early cystic fibrosis lung disease detection tools in school aged children
Verf.angabe:Katie J Bayfield, Oliver Weinheimer, Anna Middleton, Christie Boyton, Rachel Fitzpatrick, Brendan Kennedy, Anneliese Blaxland, Geshani Jayasuriya, Neil Caplain, Mark O Wielpütz, Lifeng Yu, Craig J Galban, Terry E Robinson, Brian Bartholmai, Per Gustafsson, Dominic Fitzgerald, Hiran Selvadurai, Paul D Robinson
E-Jahr:2024
Jahr:4 July 2024
Umfang:8 S.
Fussnoten:Gesehen am 14.05.2025
Titel Quelle:Enthalten in: Journal of cystic fibrosis
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 2002
Jahr Quelle:2024
Band/Heft Quelle:23(2024), 5, Seite 918-925
ISSN Quelle:1873-5010
Abstract:Background - Effective detection of early lung disease in cystic fibrosis (CF) is critical to understanding early pathogenesis and evaluating early intervention strategies. We aimed to compare ability of several proposed sensitive functional tools to detect early CF lung disease as defined by CT structural disease in school aged children. - Methods - 50 CF subjects (mean±SD 11.2 ± 3.5y, range 5-18y) with early lung disease (FEV1≥70 % predicted: 95.7 ± 11.8 %) performed spirometry, Multiple breath washout (MBW, including trapped gas assessment), oscillometry, cardiopulmonary exercise testing (CPET) and simultaneous spirometer-directed low-dose CT imaging. CT data were analysed using well-evaluated fully quantitative software for bronchiectasis and air trapping (AT). - Results - CT bronchiectasis and AT occurred in 24 % and 58 % of patients, respectively. Of the functional tools, MBW detected the highest rates of abnormality: Scond 82 %, MBWTG RV 78 %, LCI 74 %, MBWTG IC 68 % and Sacin 51 %. CPET VO2peak detected slightly higher rates of abnormality (9 %) than spirometry-based FEV1 (2 %). For oscillometry AX (14 %) performed better than Rrs (2 %) whereas Xrs and R5-19 failed to detect any abnormality. LCI and Scond correlated with bronchiectasis (r = 0.55-0.64, p < 0.001) and AT (r = 0.73-0.74, p < 0.001). MBW-assessed trapped gas was detectable in 92 % of subjects and concordant with CT-assessed AT in 74 %. - Conclusions - Significant structural and functional deficits occur in early CF lung disease, as detected by CT and MBW. For MBW, additional utility, beyond that offered by LCI, was suggested for Scond and MBW-assessed gas trapping. Our study reinforces the complementary nature of these tools and the limited utility of conventional oscillometry and CPET in this setting.
DOI:doi:10.1016/j.jcf.2024.05.012
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.jcf.2024.05.012
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S1569199324000754
 DOI: https://doi.org/10.1016/j.jcf.2024.05.012
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cystic fibrosis
 Early disease detection
 Outcome measures
 Paediatrics
K10plus-PPN:192566810X
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69344859   QR-Code
zum Seitenanfang