Multiple sclerosis: glial cell diversity in time and space

• Verfasst von: Kooistra, Susanne M. [VerfasserIn]
• Verfasst von: Schirmer, Lucas [VerfasserIn]
• Titel: Multiple sclerosis: glial cell diversity in time and space
• Titelzusatz: special issue article
• Verf.angabe: Susanne M. Kooistra, Lucas Schirmer
• E-Jahr: 2025
• Jahr: March 2025
• Umfang: 17 S.
• Fussnoten: Erstmals veröffentlicht: 24. Dezember 2024 ; Gesehen am 15.05.2025
• Weitere Titel: Titel des übergeordneten Special issue: Glial omics: unraveling mechanisms in health and disease
• Titel Quelle: Enthalten in: Glia
• Ort Quelle: Bognor Regis [u.a.] : Wiley-Liss, 1988
• Jahr Quelle: 2025
• Band/Heft Quelle: 73(2025), 3, Special issue vom: März, Seite 574-590
• ISSN Quelle: 1098-1136
• DOI: doi:10.1002/glia.24655
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: astrocytes
• Sach-SW: demyelination
• Sach-SW: microglia
• Sach-SW: neuroinflammation
• Sach-SW: oligodendrocytes
• K10plus-PPN: 1925720616

Abstract

Multiple sclerosis (MS) is the most prevalent human inflammatory disease of the central nervous system with demyelination and glial scar formation as pathological hallmarks. Glial cells are key drivers of lesion progression in MS with roles in both tissue damage and repair depending on the surrounding microenvironment and the functional state of the individual glial subtype. In this review, we describe recent developments in the context of glial cell diversity in MS summarizing key findings with respect to pathological and maladaptive functions related to disease-associated glial subtypes. A particular focus is on the spatial and temporal dynamics of glial cells including subtypes of microglia, oligodendrocytes, and astrocytes. We contextualize recent high-dimensional findings suggesting that glial cells dynamically change with respect to epigenomic, transcriptomic, and metabolic features across the inflamed rim and during the progression of MS lesions. In summary, detailed knowledge of spatially restricted glial subtype functions is critical for a better understanding of MS pathology and its pathogenesis as well as the development of novel MS therapies targeting specific glial cell types.