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Status: Bibliographieeintrag

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Verfasst von:Baumann, Lukas [VerfasserIn]   i
 Sauer, Lukas [VerfasserIn]   i
 Kieser, Meinhard [VerfasserIn]   i
Titel:A basket trial design based on power priors
Verf.angabe:Lukas Baumann, Lukas D. Sauer & Meinhard Kieser
Jahr:2024
Umfang:11 S.
Fussnoten:Online veröffentlicht: 11. November 2024 ; Gesehen am 15.05.2025
Titel Quelle:Enthalten in: Statistics in biopharmaceutical research
Ort Quelle:Alexandria, Va. : ASA, 2009
Jahr Quelle:2024
Band/Heft Quelle:(2024), Seite 1-11
ISSN Quelle:1946-6315
Abstract:In basket trials a treatment is investigated in several subgroups. They are primarily used in oncology in early clinical phases as single-arm trials with a binary endpoint. For their analysis primarily Bayesian methods have been suggested, as they allow partial sharing of information based on the observed similarity between subgroups. Fujikawa et al. suggested an approach using empirical Bayes methods that allows flexible sharing based on easily interpretable weights derived from the Jensen-Shannon divergence between the subgroup-wise posterior distributions. We show that this design is closely related to the method of power priors and investigate several modifications of Fujikawa’s design using methods from the power prior literature. While in Fujikawa’s design, the amount of information that is shared between two baskets is only determined by their pairwise similarity, we also discuss extensions where the outcomes of all baskets are considered in the computation of the sharing weights. The results of our comparison study show that the power prior design has comparable performance to fully Bayesian designs in a range of different scenarios. At the same time, the power prior design is computationally cheap and even allows analytical computation of operating characteristics in some settings.
DOI:doi:10.1080/19466315.2024.2402275
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1080/19466315.2024.2402275
 DOI: https://doi.org/10.1080/19466315.2024.2402275
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Basket trial
 Early-phase trial
 Information sharing
 Power prior
K10plus-PPN:1925743004
Verknüpfungen:→ Zeitschrift

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