| Online-Ressource |
Verfasst von: | Yang, Wuchen [VerfasserIn]  |
| Yang, Huizhen [VerfasserIn]  |
| Zhang, Quncheng [VerfasserIn]  |
| Herth, Felix [VerfasserIn]  |
| Zhang, Xiaoju [VerfasserIn]  |
Titel: | Comparison between endobronchial ultrasound-guided transbronchial node biopsy and transbronchial needle aspiration |
Titelzusatz: | a meta-analysis |
Verf.angabe: | Wuchen Yang, Huizhen Yang, Quncheng Zhang, Felix J.F. Herth, Xiaoju Zhang |
E-Jahr: | 2024 |
Jahr: | December 2024 |
Umfang: | 13 S. |
Fussnoten: | Online verfügbar: 13. August 2024 ; Gesehen am 15.05.2025 |
Titel Quelle: | Enthalten in: Respiration |
Ort Quelle: | Basel : Karger, 1968 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 103(2024), 12 vom: Dez., Seite 752-764 |
ISSN Quelle: | 1423-0356 |
Abstract: | Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can be limited by the inadequacy of intact tissues, especially in patients with lymphoma, sarcoidosis, and lymph node tuberculosis. A novel technique called transbronchial node biopsy (TBNB) by forceps or cryoprobe has been proposed and studied to improve specimen quality and diagnostic yield. We performed a systematic review of studies describing the safety and sensitivity of EBUS-TBNB versus EBUS-TBNA in diagnosing intrathoracic lymphadenopathy/masses. Methods: We systematically searched MEDLINE, Embase, Cochrane, and China National Knowledge Infrastructure to identify studies focusing on the application of EBUS-TBNB for diagnosis of intrathoracic lymphadenopathy. The quality of each study was evaluated using the QUADAS-2 tool. Using inverse-variance (I-V) weighting, we performed a meta-analysis of diagnostic yield estimations. We also reviewed the complications related to the procedure. Results: Thirteen studies were included in the final analysis. The meta-analysis yielded a pooled overall diagnostic yield of 77.80% (939/1,207) for EBUS-TBNA and 86.01% (834/958) for EBUS-TBNB, with an inverse-variance-weighted odds ratio of 3.13 (95% confidence interval [CI], 1.61-6.01; p = 0.0008) and I2 of 82%. The pooled diagnostic yield of EBUS-TBNB versus EBUS-TBNA for the diagnosis of malignancy (including primary lung cancer and extrapulmonary malignancy) was 84.53% (590/698) for EBUS-TBNA and 90.84% (476/524) for EBUS-TBNB, with an I-V-weighted OR of 2.33 (95% CI, 1.15-4.74; p = 0.02) and I2 of 64%. The pooled diagnostic yield of EBUS-TBNB versus EBUS-TBNA for the diagnosis of benignancy was 71.19% (252/354) for EBUS-TBNA and 86.62% (233/269) for EBUS-TBNB, with an I-V-weighted OR of 4.39 (95% CI, 2.00-9.65; p = 0.002) and I2 of 59%. The overall complications included bleeding (n = 11, 0.90%), pneumomediastinum (n = 6, 0.49%), pneumothorax (n = 6, 0.49%), pneumonia (n = 4, 0.33%), respiratory failure (n = 1, 0.08%), and haemoptysis (n = 1, 0.08%). The funnel plot analysis illustrated no major publication bias. Conclusions: EBUS-TBNB improves the overall diagnostic yield of sampling intrathoracic lymphadenopathy and mass lesions relative to EBUS-TBNA. The complication rate of EBUS-TBNB is higher than that of EBUS-TBNA but reportedly lower than that of surgical biopsies. |
DOI: | doi:10.1159/000540859 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1159/000540859 |
| Volltext: https://karger.com/res/article-abstract/103/12/752/911827/Comparison-between-Endobronchial-Ultrasound-Guided?redirectedF ... |
| DOI: https://doi.org/10.1159/000540859 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1925744302 |
Verknüpfungen: | → Zeitschrift |
Comparison between endobronchial ultrasound-guided transbronchial node biopsy and transbronchial needle aspiration / Yang, Wuchen [VerfasserIn]; December 2024 (Online-Ressource)