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Verfasst von:Neemann, Franziska [VerfasserIn]   i
 Jansen, Lina [VerfasserIn]   i
 Hermann, Silke [VerfasserIn]   i
 Silcher, Christian [VerfasserIn]   i
 Hettler, Madelaine Henny [VerfasserIn]   i
 Hohenberger, Peter [VerfasserIn]   i
 Callegaro, Dario [VerfasserIn]   i
 Gronchi, Alessandro [VerfasserIn]   i
 Fiore, Marco [VerfasserIn]   i
 Miceli, Rosalba [VerfasserIn]   i
 Van Coevorden, Frits [VerfasserIn]   i
 Van Houdt, Winan [VerfasserIn]   i
 Bonvalot, Sylvie [VerfasserIn]   i
 Rutkowski, Piotr [VerfasserIn]   i
 Skoczylas, Jacek [VerfasserIn]   i
 Swallow, Carol J. [VerfasserIn]   i
 Gladdy, Rebecca [VerfasserIn]   i
 Strauss, Dirk C. [VerfasserIn]   i
 Hayes, Andrew [VerfasserIn]   i
 Fairweather, Mark [VerfasserIn]   i
 Raut, Chandrajit P. [VerfasserIn]   i
 Jakob, Jens [VerfasserIn]   i
Titel:Comparing epidemiological and clinical data from RPS patients documented in a German cancer registry to a cohort from TARPSWG reference centres
Verf.angabe:Franziska Neemann, Lina Jansen, Silke Hermann, Christian Silcher, Madelaine Hettler, Peter Hohenberger, Dario Callegaro, Alessandro Gronchi, Marco Fiore, Rosalba Miceli, Frits Van Coevorden, Winan Van Houdt, Sylvie Bonvalot, Piotr Rutkowski, Jacek Skoczylas, Carol J. Swallow, Rebecca Gladdy, Dirk C. Strauss, Andrew Hayes, Mark Fairweather, Chandrajit P. Raut, Jens Jakob
E-Jahr:2024
Jahr:28 November 2024
Umfang:12 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 20.05.2025
Titel Quelle:Enthalten in: Journal of cancer research and clinical oncology
Ort Quelle:Berlin : Springer, 1979
Jahr Quelle:2024
Band/Heft Quelle:150(2024), 12, Seite 1-12
ISSN Quelle:1432-1335
Abstract:Purpose Retroperitoneal sarcomas (RPS) are rare, heterogeneous tumours. Treatment recommendations are mainly derived from cohorts treated at reference centres. The applicability of data from cancer registries (CR) is controversial. This work compares CR and TARPSWG (Transatlantic Australasian Retroperitoneal Sarcoma Working Group) data to assess the representativeness of the TARPSWG and the applicability of the CR data. Methods TARPSWG cohort has previously been described. The CR Baden-Württemberg cohort includes patients with primary RPS M0 (years 2016-2021, ICD-10 C.49.4/5, C48.x) who underwent surgery within 12 months. Only patients with sarcoma-typical histology codes as used for the German Cancer Society certification system were included. Patient, tumour and therapy factors as well as survival times were compared with Chi2-test, Kaplan Meier curves, and adjusted models. Results 1000 (TARPSWG) and 364 (CR) patients were included. CR patients were older (median: 64 years vs. 58 years), had more high-grade tumours (FNCLCC 3 48.1% vs. 27.4%, p < 0.0001) and the 5-year survival rate was significantly lower (56.3% vs. 67.9%, p = 0.0015). The proportions of dedifferentiated liposarcoma (CR 37.1% vs. 37.0%) and leiomyosarcoma (CR 20.1% vs. 19.2%), and patterns of recurrence in these most frequent RPS subtypes were similar. Conclusion ICD-O/ICD 10 based filters appear to be a valid tool for extracting RPS cases from CR. The similar distribution and biological behavior of distinct RPS subtypes suggests that TARPS-WG are representative, and CR data may be used to verify recommendations derived from reference centre cohorts. Complementary use of data from different sources warrants further investigation in rare cancers.
DOI:doi:10.1007/s00432-024-06033-5
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1007/s00432-024-06033-5
 kostenfrei: Volltext: https://link.springer.com/article/10.1007/s00432-024-06033-5
 DOI: https://doi.org/10.1007/s00432-024-06033-5
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1926108078
Verknüpfungen:→ Zeitschrift

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