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| Verfasst von: | Fehrentz, Timm [VerfasserIn]  |
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| | Amin, Ehsan [VerfasserIn] |
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| | Görldt, Nicole [VerfasserIn] |
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| | Strasdeit, Tobias [VerfasserIn] |
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| | Moussavi-Torshizi, Seyed-Erfan [VerfasserIn] |
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| | Leippe, Philipp [VerfasserIn] |
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| | Trauner, Dirk [VerfasserIn] |
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| | Meyer, Christian [VerfasserIn] |
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| | Frey, Norbert [VerfasserIn] |
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| | Sasse, Philipp [VerfasserIn] |
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| | Klöcker, Nikolaj [VerfasserIn] |
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| Titel: | Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2 |
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| Verf.angabe: | Timm Fehrentz, Ehsan Amin, Nicole Görldt, Tobias Strasdeit, Seyed-Erfan Moussavi-Torshizi, Philipp Leippe, Dirk Trauner, Christian Meyer, Norbert Frey, Philipp Sasse, Nikolaj Klöcker |
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| E-Jahr: | 2025 |
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| Jahr: | March 2025 |
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| Umfang: | 18 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 14. November 2024 ; Gesehen am 26.05.2025 |
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| Titel Quelle: | Enthalten in: British journal of pharmacology |
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| Ort Quelle: | Malden, MA : Wiley, 1946 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 182(2025), 5 vom: März, Seite 1125-1142 |
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| ISSN Quelle: | 1476-5381 |
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| Abstract: | Background and Purpose Patients suffering from ischaemic heart disease and heart failure are at high risk of recurrent ventricular arrhythmias (VAs), eventually leading to sudden cardiac death. While high-voltage shocks delivered by an implantable defibrillator may prevent sudden cardiac death, these interventions themselves impair quality of life and raise both morbidity and mortality, which accentuates the need for developing novel defibrillation techniques. Experimental Approach Photopharmacology allows for reversible control of biological processes by light. When relying on synthetic and externally applied chromophores, it renders genetic modification of target cells dispensable and may hence be advantageous over optogenetic approaches. Here, the photochromic ligand azobupivacaine 2 (AB2) was probed as a modulator of cardiac electrophysiology in an ex vivo intact mouse heart model. Key Results By reversibly blocking voltage-gated Na+ and K+ channels, photoswitching of AB2 modulated both the ventricular effective refractory period and the conduction velocity in native heart tissue. Moreover, photoswitching of AB2 was able to convert VA into sinus rhythm. Conclusion and Implications The present study provides the first proof of concept that AB2 enables gradual control of cardiac electrophysiology by light. AB2 may hence open the door to the development of an optical defibrillator based on photopharmacology. |
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| DOI: | doi:10.1111/bph.17394 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1111/bph.17394 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bph.17394 |
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| | DOI: https://doi.org/10.1111/bph.17394 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | action potential duration |
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| | conduction velocity |
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| | optical defibrillation |
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| | photopharmacology |
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| | ventricular arrhythmia |
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| | voltage-gated potassium channel |
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| | voltage-gated sodium channel |
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| K10plus-PPN: | 1926608844 |
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| Verknüpfungen: | → Zeitschrift |
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Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2 / Fehrentz, Timm [VerfasserIn]; March 2025 (Online-Ressource)
