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| Verfasst von: | Santol, Jonas [VerfasserIn]  |
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| | Kim, Sarang [VerfasserIn] |
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| | Gregory, Lindsey A. [VerfasserIn] |
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| | Baumgartner, Ruth [VerfasserIn] |
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| | Murtha-Lemekhova, Anastasia [VerfasserIn] |
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| | Birgin, Emrullah [VerfasserIn] |
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| | Gloor, Severin [VerfasserIn] |
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| | Braunwarth, Eva [VerfasserIn] |
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| | Ammann, Markus [VerfasserIn] |
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| | Starlinger, Johannes [VerfasserIn] |
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| | Pereyra, David [VerfasserIn] |
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| | Ammon, Daphni [VerfasserIn] |
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| | Ninkovic, Marijana [VerfasserIn] |
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| | Kern, Anna E. [VerfasserIn] |
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| | Rumpf, Benedikt [VerfasserIn] |
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| | Ortmayr, Gregor [VerfasserIn] |
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| | Herrmann, Yannic [VerfasserIn] |
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| | Dong, Yawen [VerfasserIn] |
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| | Huber, Felix X. [VerfasserIn] |
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| | Weninger, Jeremias [VerfasserIn] |
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| | Thiels, Cornelius A. [VerfasserIn] |
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| | Warner, Susanne G. [VerfasserIn] |
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| | Smoot, Rory L. [VerfasserIn] |
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| | Truty, Mark J. [VerfasserIn] |
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| | Kendrick, Michael L. [VerfasserIn] |
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| | Nagorney, David M. [VerfasserIn] |
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| | Cleary, Sean P. [VerfasserIn] |
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| | Beldi, Guido [VerfasserIn] |
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| | Rahbari, Nuh Nabi [VerfasserIn] |
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| | Hoffmann, Katrin [VerfasserIn] |
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| | Gilg, Stefan [VerfasserIn] |
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| | Assinger, Alice [VerfasserIn] |
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| | Gruenberger, Thomas [VerfasserIn] |
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| | Hackl, Hubert [VerfasserIn] |
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| | Starlinger, Patrick [VerfasserIn] |
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| Titel: | An APRI+ALBI-based multivariable model as a preoperative predictor for posthepatectomy liver failure |
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| Verf.angabe: | Jonas Santol, MD, Sarang Kim, Lindsey A. Gregory, PA-C, MS, Ruth Baumgartner, MD, Anastasia Murtha-Lemekhova, MD, Emrullah Birgin, MD, Severin Gloor, MD, Eva Braunwarth, MD, Markus Ammann, MD, Johannes Starlinger, MD, PhD, David Pereyra, MD, PhD, Daphni Ammon, MD, Marijana Ninkovic, MD, Anna E. Kern, Benedikt Rumpf, MD, Gregor Ortmayr, MD, Yannic Herrmann, Yawen Dong, MD, Felix X. Huber, Jeremias Weninger, Cornelius A. Thiels, DO, MBA, Susanne G. Warner, MD, Rory L. Smoot, MD, Mark J. Truty, MD, Michael L. Kendrick, MD, David M. Nagorney, MD, Sean P. Cleary, MD, Guido Beldi, MD, Nuh N. Rahbari, MD, Katrin Hoffmann, MD, MBA, Stefan Gilg, MD, PhD, Alice Assinger, PhD, Thomas Gruenberger, MD,* Hubert Hackl, PhD, and Patrick Starlinger, MD, PhD |
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| E-Jahr: | 2025 |
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| Jahr: | May 2025 |
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| Umfang: | 11 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 27.05.2025 |
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| Titel Quelle: | Enthalten in: Annals of surgery |
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| Ort Quelle: | [Erscheinungsort nicht ermittelbar] : Lippincott Williams & Wilkins, 1885 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 281(2025), 5, Seite 861-871 |
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| ISSN Quelle: | 1528-1140 |
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| Abstract: | Objective and Background: - Clinically significant posthepatectomy liver failure (PHLF B+C) remains the main cause of mortality after major hepatic resection. This study aimed to establish an aspartate aminotransferase to platelet ratio combined with an albumin-bilirubin grade (APRI+ALBI), based multivariable model (MVM) to predict PHLF and compare its performance to indocyanine green clearance (ICG-R15 or ICG-PDR) and albumin-ICG evaluation (ALICE). - Methods: - A total of 12,056 patients from the National Surgical Quality Improvement Program database were used to generate a MVM to predict PHLF B+C. The model was determined using stepwise backwards elimination. The performance of the model was tested using receiver operating characteristic curve analysis and validated in an international cohort of 2525 patients. In 620 patients, the APRI+ALBI MVM, trained in the National Surgical Quality Improvement Program cohort, was compared with the MVM’s based on other liver function tests (ICG clearance, ALICE) by comparing the areas under the curve (AUC). - Results: - A MVM including APRI+ALBI, age, sex, tumor type, and extent of resection was found to predict PHLF B+C with an AUC of 0.77, with comparable performance in the validation cohort (AUC: 0.74). In direct comparison with other MVM’s based on more expensive and time-consuming liver function tests (ICG clearance, ALICE), the APRI+ALBI MVM demonstrated equal predictive potential for PHLF B+C. A smartphone application for the calculation of the APRI+ALBI MVM was designed. - Conclusion: - Risk assessment through the APRI+ALBI MVM for PHLF B+C increases preoperative predictive accuracy and represents a universally available and cost-effective risk assessment before hepatectomy, facilitated by a freely available smartphone app. |
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| DOI: | doi:10.1097/SLA.0000000000006127 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1097/SLA.0000000000006127 |
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| | kostenfrei: Volltext: https://journals.lww.com/annalsofsurgery/fulltext/2025/05000/an_apri_albi_based_multivariable_model_as_a.20.aspx |
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| | DOI: https://doi.org/10.1097/SLA.0000000000006127 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1926704851 |
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| Verknüpfungen: | → Zeitschrift |
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¬An¬ APRI+ALBI-based multivariable model as a preoperative predictor for posthepatectomy liver failure / Santol, Jonas [VerfasserIn]; May 2025 (Online-Ressource)
