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| Verfasst von: | Recher, Christian [VerfasserIn]  |
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| | Dumas, Pierre-Yves [VerfasserIn] |
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| | Bérard, Emilie [VerfasserIn] |
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| | Tavitian, Suzanne [VerfasserIn] |
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| | Leguay, Thibaut [VerfasserIn] |
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| | Galtier, Jean [VerfasserIn] |
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| | Alric, Camille [VerfasserIn] |
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| | Bidet, Audrey [VerfasserIn] |
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| | Delabesse, Eric [VerfasserIn] |
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| | Rieu, Jean Baptiste [VerfasserIn] |
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| | Vial, Jean-Philippe [VerfasserIn] |
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| | Vergez, François [VerfasserIn] |
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| | Luquet, Isabelle [VerfasserIn] |
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| | Klein, Emilie [VerfasserIn] |
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| | de Grande, Anne-Charlotte [VerfasserIn] |
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| | Sarry, Audrey [VerfasserIn] |
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| | Zukunft, Sven [VerfasserIn] |
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| | Platzbecker, Uwe [VerfasserIn] |
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| | Müller-Tidow, Carsten [VerfasserIn] |
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| | Baldus, Claudia D. [VerfasserIn] |
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| | Bornhäuser, Martin [VerfasserIn] |
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| | Serve, Hubert [VerfasserIn] |
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| | Bertoli, Sarah [VerfasserIn] |
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| | Pigneux, Arnaud [VerfasserIn] |
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| | Röllig, Christoph [VerfasserIn] |
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| Titel: | Mini-consolidations or intermediate-dose cytarabine for the post-remission therapy of AML patients over 60 |
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| Titelzusatz: | a retrospective study from the DATAML and SAL registries |
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| Verf.angabe: | Christian Récher, Pierre-Yves Dumas, Emilie Bérard, Suzanne Tavitian, Thibaut Leguay, Jean Galtier, Camille Alric, Audrey Bidet, Eric Delabesse, Jean Baptiste Rieu, Jean-Philippe Vial, François Vergez, Isabelle Luquet, Emilie Klein, Anne-Charlotte de Grande, Audrey Sarry, Sven Zukunft, Uwe Platzbecker, Carsten Müller-Tidow, Claudia D. Baldus, Martin Bornhäuser, Hubert Serve, Sarah Bertoli, Arnaud Pigneux, Christoph Röllig |
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| E-Jahr: | 2025 |
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| Jahr: | January 2025 |
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| Umfang: | 10 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Online verfügbar: 18. November 2024 ; Gesehen am 27.05.2025 |
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| Titel Quelle: | Enthalten in: American journal of hematology |
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| Ort Quelle: | New York, NY : Wiley-Liss, 1976 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 100(2025), 1, Seite 23-32 |
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| ISSN Quelle: | 1096-8652 |
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| Abstract: | According to current recommendations, older AML patients in first complete remission (CR) after induction chemotherapy should receive consolidation with intermediate-dose cytarabine (IDAC). However, no study has demonstrated the superiority of IDAC over other regimen. In this retrospective study, we compared the efficacy of mini-consolidations (idarubicin 8 mg/m2 day 1, cytarabine 50 mg/m2/12 h, day 1-5) and IDAC. Inclusion criteria were newly diagnosed AML, age > 60 years, first CR after induction and at least 1 cycle of consolidation. Of the 796 included patients, 322 patients received mini-consolidations and 474 patients received IDAC. Mini-consolidation patients were older, and more often, they had de novo AML and unfavorable risk. The rate of allogeneic transplantation was higher in the IDAC group. The median number of cycles was higher in the mini-consolidation group (4 vs. 2; p < .0001). Median relapse-free survival was 18 months with mini-consolidations and 12 months with IDAC (p = .0064). In multivariate analysis, the risk of relapse or death was significantly higher in the IDAC group (p = .004). Median OS was 36 versus 31 months with mini-consolidations or IDAC, respectively (p = .46). In multivariate analysis, the consolidation regimen had no significant influence on OS (p = .43). In older AML patients, post-remission therapy with mini-consolidations represents an alternative to IDAC. |
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| DOI: | doi:10.1002/ajh.27510 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/ajh.27510 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ajh.27510 |
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| | DOI: https://doi.org/10.1002/ajh.27510 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1926812042 |
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| Verknüpfungen: | → Zeitschrift |
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Mini-consolidations or intermediate-dose cytarabine for the post-remission therapy of AML patients over 60 / Recher, Christian [VerfasserIn]; January 2025 (Online-Ressource)
