Increased levels of leukocyte elastase in ischemic stroke and in subjects with vascular risk factors

• Verfasst von: Grau, Armin J. [VerfasserIn]
• Verfasst von: Seitz, Rainer [VerfasserIn]
• Verfasst von: Immel, Anette [VerfasserIn]
• Verfasst von: Steichen-Wiehn, Christianne [VerfasserIn]
• Verfasst von: Hacke, Werner [VerfasserIn]
• Titel: Increased levels of leukocyte elastase in ischemic stroke and in subjects with vascular risk factors
• Verf.angabe: Armin J. Grau, Rainer Seitz, Anette Immel, Christianne Steichen-Wiehn, Werner Hacke
• E-Jahr: 1995
• Jahr: February 22 1995
• Umfang: 5 S.
• Fussnoten: Gesehen am 02.06.2025
• Titel Quelle: Enthalten in: Cerebrovascular diseases
• Ort Quelle: Basel : Karger, 1991
• Jahr Quelle: 1995
• Band/Heft Quelle: 5(1995), 1, Seite 50-54
• ISSN Quelle: 1421-9786
• DOI: doi:10.1159/000107819
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1927234700

Abstract

Proteolytic enzymes by polymorphonuclear leukocytes such as elastase may contribute to the pathogenesis of acute cerebral ischemia. We measured elastase α1-protease inhibitor complexes (EIC) in acute ischemic stroke and in controls with and without vascular risk factors. Levels of EIC were higher in patients (n = 24, 51.4 ± 18.5 ng/ml) than in healthy controls (n = 26, 36.2 ± 11.5 ng/ml, p < 0.001) but not higher than in controls with risk factors (n = 22, 53.4 ± 29.6 ng/ml). Stroke patients with recent or concomitant infections had higher EIC levels than all other groups (n = 14, 71.0 ± 24.6 ng/ml). This result suggests leukocyte activation in acute stroke and in subjects with increased risk for stroke.