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| Verfasst von: | Liu, Hanting [VerfasserIn]  |
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| | Zou, Maosheng [VerfasserIn] |
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| | Shen, Mingwang [VerfasserIn] |
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| | Kamarulzaman, Adeeba [VerfasserIn] |
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| | Chen, Simiao [VerfasserIn] |
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| | Li, Jinghua [VerfasserIn] |
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| | Li, Rui [VerfasserIn] |
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| | Liu, Huan [VerfasserIn] |
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| | Zou, Zhuoru [VerfasserIn] |
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| | Zhang, Lei [VerfasserIn] |
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| Titel: | HPV vaccination is highly effective and cost-effective for cervical cancer prevention in women living with HIV in China |
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| Titelzusatz: | a cost-effectiveness analysis |
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| Verf.angabe: | Hanting Liu, Maosheng Zou, Mingwang Shen, Adeeba Kamarulzaman, Simiao Chen, Jinghua Li, Rui Li, Huan Liu, Zhuoru Zou, Lei Zhang |
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| E-Jahr: | 2025 |
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| Jahr: | 15 March 2025 |
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| Umfang: | 11 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 17. November 2024 ; Gesehen am 02.06.2025 |
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| Titel Quelle: | Enthalten in: International journal of cancer |
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| Ort Quelle: | Bognor Regis : Wiley-Liss, 1966 |
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| Jahr Quelle: | 2025 |
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| Band/Heft Quelle: | 156(2025), 6, Seite 1225-1235 |
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| ISSN Quelle: | 1097-0215 |
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| Abstract: | The presence of human immunodeficiency virus (HIV) infection increases the risk of acquiring human papillomavirus (HPV) infection and developing HPV-related adversities. We aimed to estimate the cost-effectiveness of HPV vaccination for women living with HIV in a Chinese setting. A decision-analysis Markov model was developed to estimate the cost-effectiveness of 36 HPV vaccination strategies for women living with HIV aged 18-45 years, from the healthcare system perspective. With the status quo, not vaccinating women living with HIV would lead to 51.99% (51,985/100,000) HIV-related deaths; 35.10% (35,098/100,000) would develop genital warts, 0.36% (355/100,000) develop cervical cancer, and among which 63.66% (226/355) die from cervical cancer over their lifetime (1,601,457 person-years). With a willingness to pay (WTP) threshold of three times gross domestic product (GDP), Gardasil 4 vaccination for all women living with HIV aged 18-45 years was the most cost-effective strategy (ICER = US \32,766/QALY gained). This strategy would reduce genital warts by 35.52% (12,467/35,098), cervical cancers by 12.96% (46/355), and cervical cancer deaths by 12.39% (28/226) over the lifetime of the cohort. If the future domestic Cecolin 9 vaccine is priced at 60% of Gardasil 9, vaccinating all women living with HIV aged 18-45 years with Cecolin 9 would be the most cost-effective strategy (ICER = US \30,493/QALY gained). Improving adherence to antiretroviral therapy for HIV may substantially improve the cost-effectiveness of both Gardasil 4 and Cecolin 9 vaccination. |
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| DOI: | doi:10.1002/ijc.35242 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1002/ijc.35242 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.35242 |
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| | DOI: https://doi.org/10.1002/ijc.35242 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cervical cancer |
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| | cost-effectiveness analysis |
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| | human immunodeficiency virus |
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| | human papillomavirus |
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| | vaccine |
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| K10plus-PPN: | 1927249791 |
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| Verknüpfungen: | → Zeitschrift |
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HPV vaccination is highly effective and cost-effective for cervical cancer prevention in women living with HIV in China / Liu, Hanting [VerfasserIn]; 15 March 2025 (Online-Ressource)
